Viruses, 2019 Fusion of viral and cellular membranes is a key step during the viral life cycle. Enveloped viruses trigger this process by means of specialized viral proteins expressed on their surface, the so-called viral fusion proteins.
María J. García-Murria +4 more
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Influence of N-glycosylation on Expression and Function of Pseudorabies Virus Glycoprotein gB
Pathogens, 2021 Envelope glycoprotein (g)B is conserved throughout the Herpesviridae and mediates fusion of the viral envelope with cellular membranes for infectious entry and spread.
Melina Vallbracht +2 more
doaj +1 more source
Frontiers in Microbiology, 2021 The SARS-CoV-2 viral genome contains a positive-strand single-stranded RNA of ∼30 kb. Human ACE2 protein is the receptor for SARS-CoV-2 virus attachment and infection.
Shuang-yong Xu +3 more
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Interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity [PDF]
arXiv, 2022 Enveloped viral infections require fusion with cellular membranes for viral genome entry, occurring only following interaction of viral and cellular membranes allowing fusion pore formation, by which the virus accesses the cytoplasm. Here, we focus on interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity. IFITM3 is predicted to
arxiv
Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion. [PDF]
PLoS ONE, 2007 The SARS coronavirus (SARS-CoV) spike is the largest known viral spike molecule, and shares a similar function with all class 1 viral fusion proteins.
Daniel R Beniac +4 more
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A compact, multifunctional fusion module directs cholesterol-dependent homomultimerization and syncytiogenic efficiency of reovirus p10 FAST proteins. [PDF]
PLoS Pathogens, 2014 The homologous p10 fusion-associated small transmembrane (FAST) proteins of the avian (ARV) and Nelson Bay (NBV) reoviruses are the smallest known viral membrane fusion proteins, and are virulence determinants of the fusogenic reoviruses.
Tim Key, Roy Duncan
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Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2 [PDF]
, 2005 In this study we analysed the outcome of the interaction between HPV-16 L2 and E2 on the transactivation and DNA replication functions of E2. When E2 was expressed on its own, it transactivated a number of E2-responsive promoters but co-expression of L2 ...
A. Okoye +32 more
core +1 more source
Structure and Neutralization of Viral Fusion Proteins
, 2023 Emerging infectious diseases remain persistent threats that are challenging to predict. Humanity has faced many terrible pandemics and will face more, but to pinpoint the specific time and place of an outbreak, the type of pathogen, and the consequences is effectively impossible.
openaire +2 more sources
Classification of capped tubular viral particles in the family of Papovaviridae [PDF]
J.Phys.:Condens.Matter 18 (2006) S375-S387, 2005 A vital constituent of a virus is its protein shell, called the viral capsid, that encapsulates and hence provides protection for the viral genome. Viral capsids are usually spherical, and for a significant number of viruses exhibit overall icosahedral symmetry.
arxiv +1 more source
Functional domains of the influenza A virus PB2 protein:identification of NP- and PB1-binding sites [PDF]
, 2004 Influenza virus genomic RNA segments are packaged into ribonucleoprotein (RNP) structures by the PB1, PB2, and PA subunits of an RNA polymerase and a single-strand RNA-binding nucleoprotein (NP).
Digard, Paul +3 more
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