Results 1 to 10 of about 1,648,672 (312)

Defining basic rules for hardening influenza A virus liquid condensates

eLife, 2023
In biological systems, liquid and solid-like biomolecular condensates may contain the same molecules but their behaviour, including movement, elasticity, and viscosity, is different on account of distinct physicochemical properties.
Temitope Akhigbe Etibor, Silvia Vale-Costa, Sindhuja Sridharan, Daniela Brás, Isabelle Becher, Victor Hugo Mello, Filipe Ferreira, Marta Alenquer, Mikhail M Savitski, Maria-João Amorim   +9 more
doaj   +1 more source

Increased Production of Inflammatory Cytokines after Inoculation with Recombinant Zoster Vaccine in Mice

Vaccines, 2022
Increasing numbers of patients with zoster were reported recently, and recombinant zoster vaccine (Shingrix®) was licensed using the AS01B adjuvant system.
Tetsuo Nakayama, Akihito Sawada, Takeshi Ito   +2 more
doaj   +1 more source

Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo

Nature Communications, 2023
To date, no herpesvirus has been shown to latently persist in fibroblastic cells. Here, we show that murine cytomegalovirus, a β-herpesvirus, persists for the long term and across organs in PDGFRα-positive fibroblastic cells, with similar or higher ...
Katarzyna M. Sitnik, Fran Krstanović, Natascha Gödecke, Ulfert Rand, Tobias Kubsch, Henrike Maaß, Yeonsu Kim, Ilija Brizić, Luka Čičin-Šain   +8 more
doaj   +1 more source

Chimeric Measles Virus (MV/RSV), Having Ectodomains of Respiratory Syncytial Virus (RSV) F and G Proteins Instead of Measles Envelope Proteins, Induced Protective Antibodies against RSV

Vaccines, 2021
In our previous study, fusion (F) or glyco (G) protein coding sequence of respiratory syncytial virus (RSV) was inserted at the P/M junction of the measles AIK-C vector (MVAIK), and the recombinant measles virus induced protective immune responses.
Akihito Sawada, Takashi Ito, Yoshiaki Yamaji, Tetsuo Nakayama   +3 more
doaj   +1 more source

Diminished neutralization responses towards SARS-CoV-2 Omicron VoC after mRNA or vector-based COVID-19 vaccinations

Scientific Reports, 2022
SARS-CoV-2 variants accumulating immune escape mutations provide a significant risk to vaccine-induced protection against infection. The novel variant of concern (VoC) Omicron BA.1 and its sub-lineages have the largest number of amino acid alterations in
Henning Jacobsen, Monika Strengert, Henrike Maaß, Mario Alberto Ynga Durand, Maeva Katzmarzyk, Barbora Kessel, Manuela Harries, Ulfert Rand, Leila Abassi, Yeonsu Kim, Tatjana Lüddecke, Kristin Metzdorf, Pilar Hernandez, Julia Ortmann, Jana-Kristin Heise, Stefanie Castell, Daniela Gornyk, Stephan Glöckner, Vanessa Melhorn, Yvonne Kemmling, Berit Lange, Alex Dulovic, Patrick Marsall, Julia Häring, Daniel Junker, Nicole Schneiderhan-Marra, Markus Hoffmann, Stefan Pöhlmann, Gérard Krause, Luka Cicin-Sain   +29 more
doaj   +1 more source

Cytokine and Chemokine Production in Mice Inoculated with NVX-CoV2373 (Nuvaxovid^®) in Comparison with Omicron BA.4/5 Bivalent BNT162b2 (Comirnaty^®)

Vaccines, 2023
A recombinant SARS-CoV-2 spike protein vaccine (NVX-CoV2373) has been licensed and has a lesser incidence of adverse events. To know the immunological mechanisms of adverse events, the production of cytokines and chemokines was investigated in mice ...
Tetsuo Nakayama, Takashi Ito, Ryoka Ishiyama, Kazuhiko Katayama   +3 more
doaj   +1 more source

Recombinant Measles AIK-C Vaccine Strain Expressing Influenza HA Protein

Vaccines, 2020
Recombinant measles AIK-C vaccine expressing the hemagglutinin (HA) protein of influenza A/Sapporo/107/2013(H1N1pdm) (MVAIK/PdmHA) was constructed. Measles particle agglutination (PA) and influenza hemagglutinin inhibition (HI) antibodies were induced in
Takashi Ito, Takuji Kumagai, Yoshiaki Yamaji, Akihito Sawada, Tetsuo Nakayama   +4 more
doaj   +1 more source

The potential of COVID-19 patients’ sera to cause antibody-dependent enhancement of infection and IL-6 production

Scientific Reports, 2021
Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many vaccine trials have been initiated. An important goal of vaccination is the development of neutralizing antibody (Ab) against SARS-CoV-2.
Jun Shimizu, Tadahiro Sasaki, Atsushi Yamanaka, Yoko Ichihara, Ritsuko Koketsu, Yoshihiro Samune, Pedro Cruz, Kei Sato, Naomi Tanga, Yuka Yoshimura, Ami Murakami, Misuzu Yamada, Kiyoe Itoi, Emi E. Nakayama, Kazuo Miyazaki, Tatsuo Shioda   +15 more
doaj   +1 more source

Isoforms of the Papillomavirus Major Capsid Protein Differ in Their Ability to Block Viral Spread and Tumor Formation

Frontiers in Immunology, 2022
Notably, the majority of papillomaviruses associated with a high cancer risk have the potential to translate different isoforms of the L1 major capsid protein. In an infection model, the cutaneous Mastomys natalensis papillomavirus (MnPV) circumvents the
Daniel Hasche, Melinda Ahmels, Ilona Braspenning-Wesch, Sonja Stephan, Rui Cao, Gabriele Schmidt, Martin Müller, Frank Rösl   +7 more
doaj   +1 more source

Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity

eLife, 2020
Although many high-risk mucosal and cutaneous human papillomaviruses (HPVs) theoretically have the potential to synthesize L1 isoforms differing in length, previous seroepidemiological studies only focused on the short L1 variants, co-assembling with L2 ...
Yingying Fu, Rui Cao, Miriam Schäfer, Sonja Stephan, Ilona Braspenning-Wesch, Laura Schmitt, Ralf Bischoff, Martin Müller, Kai Schäfer, Sabrina E Vinzón, Frank Rösl, Daniel Hasche   +11 more
doaj   +1 more source