Results 11 to 20 of about 1,223,168 (317)
Journal of Clinical Pathology, 1976 Although rubella is the only virus which can be regarded in the strict sense of the term a teratogen, there is no convincing evidence that other viruses can cause fetal damage of varying severity. The risk to the fetus appears to depend on the nature of the infectious agent, the maternal immune status and the gestational age when infection takes place.
L, Weinstein, T W, Chang
openaire +5 more sources
Immunosuppression in Viral Infections [PDF]
Clinical Infectious Diseases, 1986 Viruses may cause immunosuppression by a variety of mechanisms. This review delineates four categories. First, immunosuppression can result from the direct effects of viral replication on lymphocyte functions. Either all classes of lymphocytes can be affected, as occurs in measles, or the effect can be restricted to a cell subtype, as is the case with ...
B T, Rouse, D W, Horohov
openaire +2 more sources
Frontiers in Immunology, 2022 Licensed L1-VLP-based immunizations against high-risk mucosal human papillomavirus (HPV) types have been a great success in reducing anogenital cancers, although they are limited in their cross-protection against HPV types not covered by the vaccine ...
Melinda Ahmels +10 more
doaj +1 more source
Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection. [PDF]
, 2012 During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the real ...
Lisa Marcinowski +46 more
core +1 more source
Cells, 2021 Host cell-intrinsic antiviral responses are largely mediated by pattern-recognition receptor (PRR) signaling and the interferon (IFN) system. The IFN regulatory factor (IRF) family of transcription factors takes up a central role in transcriptional ...
Sandra Wüst +3 more
doaj +1 more source
Cooperative effects of RIG-I-like receptor signaling and IRF1 on DNA damage-induced cell death
Cell Death and Disease, 2022 Properly responding to DNA damage is vital for eukaryotic cells, including the induction of DNA repair, growth arrest and, as a last resort to prevent neoplastic transformation, cell death.
David Y. Zander +4 more
doaj +1 more source
Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection [PDF]
, 2002 Although antiviral agents which block human immunodeficiency virus (HIV) replication can result in long-term suppression of viral loads to undetectable levels in plasma, long-term therapy fails to eradicate virus, which generally rebounds after a single ...
Ruiz, L +9 more
core +1 more source
Influenza A virus ribonucleoproteins form liquid organelles at endoplasmic reticulum exit sites
Nature Communications, 2019 Influenza A virus forms cytosolic inclusions containing viral ribonucleoproteins. Here, the authors show that viral inclusions form juxtaposed the endoplasmic reticulum and have liquid properties, likely constituting sites of assembly of epidemic and ...
Marta Alenquer +5 more
doaj +1 more source
TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection
Viruses, 2023 The COVID-19 pandemic remains a global health threat and novel antiviral strategies are urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into lung cells, and TMPRSS2 inhibitors are being developed for COVID-19 therapy ...
Kristin Metzdorf +13 more
doaj +1 more source
One Step Ahead: Herpesviruses Light the Way to Understanding Interferon-Stimulated Genes (ISGs)
Frontiers in Microbiology, 2020 The host immune system is engaged in a constant battle with microorganisms, with the immediate detection of pathogenic invasion and subsequent signalling acting as crucial deterrents against the establishment of a successful infection.
A. Cristina Gonzalez-Perez +5 more
doaj +1 more source