Results 91 to 100 of about 605,993 (221)

Ketogenic diet fails to mitigate seizures and neuroinflammatory responses in a mouse model of virus‐induced epilepsy

Epilepsia, EarlyView.
Abstract Objective The ketogenic diet (KD) is a high‐fat, low‐carbohydrate intervention widely used to treat drug‐resistant epilepsy, thought to reduce seizures through a combination of metabolic, neuronal, and microbiota‐dependent mechanisms. Additionally, recent studies suggest that the anticonvulsant effects of KD require the gut microbiota, with ...
Casey H. Meili, Kaitlyn Allen, Daniel J. Doty, Sofia Del Fiol, Ana Beatriz DePaula‐Silva   +4 more
wiley   +1 more source

Biodiversity and distribution of polar freshwater DNA viruses [PDF]

, 2015
Viruses constitute the most abundant biological entities and a large reservoir of genetic diversity on Earth. Despite the recent surge in their study, our knowledge on their actual biodiversity and distribution remains sparse.
López-Bueno, Alberto, Pearce, David, Pearce, David A., Alcamí, Antonio, Aguirre de Cárcer, Daniel, Aguirre de Carcer, D., Pearce, D. A., Alcami, A., Lopez-Bueno, A.   +8 more
core   +3 more sources

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source

Metagenome sequence data mining for viral interaction studies: Review on progress and prospects

Virus Research
Metagenomics has been greatly accelerated by the development of next-generation sequencing (NGS) technologies, which allow scientists to discover and describe novel microorganisms without the need for conventional culture techniques.
Mohammadreza Rahimian, Bahman Panahi
doaj   +1 more source

Oral and Fecal Microbial Dysbiosis as Non‐Invasive Diagnostic Biomarkers for Gastrointestinal Cancers: A Systematic Review and Meta‐Analysis of Diagnostic Accuracy

International Journal of Cancer, EarlyView.
ABSTRACT Gastrointestinal (GI) cancers, including esophageal (EC), gastric (GC), and colorectal cancer (CRC), impose a substantial global burden, with early detection remaining crucial for improving patient outcomes. The oral and gut microbiota are increasingly implicated in cancer development and hold promise as sources of non‐invasive biomarkers ...
Saidi Hu, Zhouyan Chen, Yanxia Li, Qingyan Liao, Mingdong Luo, Danyang Song, Hanyue Yu, Yuetong Gao, Shuanglong Yang, Siran Wan, Shunhong Zhang, Chenchen Luo, Lin‐Yong Zhao   +12 more
wiley   +1 more source

Multi‐omics reveals gastrointestinal metabolic disorder‐induced diarrhea in postpartum dairy cows

iMetaOmics, EarlyView.
Nutritional diarrhea is a pervasive, costly challenge in dairy production. Using integrated metagenomic and metabolomic profiling, we identified coordinated microbial and metabolic alterations across the rumen, hindgut, and serum. In the rumen, enrichment of Prevotella sp.
Weixuan Tang, Yangyi Hao, Jiawei Zhang, Yajing Wang, Zhijun Cao, Hongjian Yang, Wei Wang, Shengli Li   +7 more
wiley   +1 more source

Review on Viral Metagenomics and Its Future Perspective in Zoonotic and Arboviral Disease Surveillance [PDF]

, 2017
Viral metagenomics or full-length genome sequencing of enriched viral particle preparations has been frequently applied for viral discovery resulting in the genetic characterization of numerous human and animal viruses. The  non- specific nature of viral
Bulcha, Begna
core   +1 more source

Single amino acid change in tomato brown rugose fruit virus breaks virus-specific resistance in new resistant tomato cultivar

Frontiers in Plant Science
IntroductionTomato cultivation across the world is severely affected by emerging plant viruses. An effective method for protection of commercial crops against viral threats is the use of cultivars harboring resistance genes.
Zafeiro Zisi, Zafeiro Zisi, Lucas Ghijselings, Elise Vogel, Elise Vogel, Christine Vos, Jelle Matthijnssens   +6 more
doaj   +1 more source

Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization

iMetaOmics, EarlyView.
Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao, Hang You, Zongyi Liu, Yong Sun, Yu Zhang, Li Wei, Ning Ling, Hong Ren, Shiying Li, Peng Hu, Mingli Peng   +10 more
wiley   +1 more source

Metagenomic Analysis of the Ferret Fecal Viral Flora

PLoS ONE, 2013
Ferrets are widely used as a small animal model for a number of viral infections, including influenza A virus and SARS coronavirus. To further analyze the microbiological status of ferrets, their fecal viral flora was studied using a metagenomics approach.
Smits, Saskia L, Raj, V Stalin, Oduber, Minoushka D, Schapendonk, Claudia M E, Bodewes, Rogier, Provacia, Lisette, Stittelaar, Koert J, Osterhaus, Albert D M E, Haagmans, Bart L   +8 more
openaire   +5 more sources