Results 71 to 80 of about 30,780 (255)

Virome drift in ulcerative colitis patients: faecal microbiota transplantation results in minimal phage engraftment dominated by microviruses

Gut Microbes
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent colonic inflammation. Standard treatments focus on controlling inflammation but remain ineffective for one-third of patients.
Daan Jansen, Sara Deleu, Clara Caenepeel, Tine Marcelis, Ceren Simsek, Gwen Falony, Kathleen Machiels, João Sabino, Jeroen Raes, Séverine Vermeire, Jelle Matthijnssens   +10 more
doaj   +1 more source

Bioinformatics tools for analysing viral genomic data [PDF]

, 2016
The field of viral genomics and bioinformatics is experiencing a strong resurgence due to high-throughput sequencing (HTS) technology, which enables the rapid and cost-effective sequencing and subsequent assembly of large numbers of viral genomes.
Davison, A., Gu, Q., Hughes, J., Maabar, M., Modha, S., Orton, R.J., Vattipally, Sreenu, Wilkie, G.S.   +7 more
core   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Overview of Trends in the Application of Metagenomic Techniques in the Analysis of Human Enteric Viral Diversity in Africa’s Environmental Regimes

Viruses, 2018
There has been an increase in the quest for metagenomics as an approach for the identification and study of the diversity of human viruses found in aquatic systems, both for their role as waterborne pathogens and as water quality indicators.
Cecilia Oluseyi Osunmakinde, Ramganesh Selvarajan, Timothy Sibanda, Bhekie B Mamba, Titus A.M Msagati   +4 more
doaj   +1 more source

Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. [PDF]

, 2019
The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism
Lynch, Susan V, Sharpton, Suzanne R, Terrault, Norah A, Yong, Germaine JM   +3 more
core   +1 more source

Bioinformatics for Viral Metagenomics [PDF]

Journal of Data Mining in Genomics & Proteomics, 2013
Detection of the presence of known and unknown viruses in biospecimens is today routinely performed using viral metagenomics. Because the sequencing speed and cost per base is rapidly declining with new next generation sequencing technologies, such as HiSeq (Illumina), 454 GS FLX (Roche), SOLiD (ABI) and Ion Torrent Proton (Life Technologies), the ...
openaire   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Surveillance of Viruses in Varroa destructor Samples Collected from Honey Bee Colonies in Ontario, Canada, between 2015 and 2019

Journal of Apicultural Science, 2022
Varroa destructor parasitism is associated with extreme honey bee (Apis mellifera) colony losses in the northern hemisphere. Varroa destructor causes severe damage, including a decrease in bee longevity and immunosuppression, and acts as a vector for ...
Morfin Nuria, Kozak Paul, Ledger Lisa, You Qiu, Bell-Rogers Patricia, Zechel Jennifer, Krishnamurthy Aparna, Slavic Durda, Guzman-Novoa Ernesto, Cai Hugh Y.   +9 more
doaj   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

VEBA: a modular end-to-end suite for in silico recovery, clustering, and analysis of prokaryotic, microeukaryotic, and viral genomes from metagenomes

BMC Bioinformatics, 2022
Background With the advent of metagenomics, the importance of microorganisms and how their interactions are relevant to ecosystem resilience, sustainability, and human health has become evident.
Josh L. Espinoza, Chris L. Dupont
doaj   +1 more source