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Gut viral metagenomics identifies viral signatures and their role in depression
Frontiers in MicrobiologyBackgroundThe gut microbiome has been implicated in the onset and progression of depression. Yet, the role of the gut virome in depression remains unexplored, and a diagnostic model has not been satisfactorily constructed.MethodsHerein, we analysed the ...
Xinyu Chen +7 more
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Integrating Viral Metagenomics into an Ecological Framework [PDF]
Annual Review of Virology, 2021 Viral metagenomics has expanded our knowledge of the ecology of uncultured viruses, within both environmental (e.g., terrestrial and aquatic) and host-associated (e.g., plants and animals, including humans) contexts. Here, we emphasize the implementation of an ecological framework in viral metagenomic studies to address questions in virology rarely ...
Pacifica, Sommers +3 more
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Rapid screening and identification of viral pathogens in metagenomic data
BMC Medical Genomics, 2021 Background Virus screening and viral genome reconstruction are urgent and crucial for the rapid identification of viral pathogens, i.e., tracing the source and understanding the pathogenesis when a viral outbreak occurs.
Shiyang Song +6 more
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Reviews in Medical Virology, 2007 AbstractCharacterisation of new viruses is often hindered by difficulties in amplifying them in cell culture, limited antigenic/serological cross‐reactivity or the lack of nucleic acid hybridisation to known viral sequences. Numerous molecular methods have been used to genetically characterise new viruses without prior in vitro replication or the use ...
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Challenges in the analysis of viral metagenomes [PDF]
Virus Evolution, 2016 Genome sequencing technologies continue to develop with remarkable pace, yet analytical approaches for reconstructing and classifying viral genomes from mixed samples remain limited in their performance and usability. Existing solutions generally target expert users and often have unclear scope, making it challenging to critically evaluate their ...
Rose, R +4 more
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Metagenomic identification of viral sequences in laboratory reagents [PDF]
Viruses, 2021 2. Abstract Metagenomic next-generation sequencing has transformed the discovery and diagnosis of infectious disease, with the power to characterize the complete ‘infectome’ (bacteria, viruses, fungi, parasites) of an individual host organism.
Ashleigh F. Porter +4 more
openaire +5 more sources
mSphere, 2019 Diarrhea remains one of the most common causes of deaths in children. A limited number of studies have investigated the prevalence of enteric pathogens in Cameroon, and as in many other African countries, the cause of many diarrheal episodes remains ...
Claude Kwe Yinda +9 more
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Diagnostic metagenomics : potential applications to bacterial, viral and parasitic infections [PDF]
, 2014 The term 'shotgun metagenomics' is applied to the direct sequencing of DNA extracted from a sample without culture or target-specific amplification or capture.
M. J. Pallen, Pallen, Mark J.
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Emerging Microbes and Infections, 2017 Sapoviruses (SaVs) belong to the Sapovirus genus, in the family Caliciviridae. They have been associated with gastroenteritis in humans and in pigs but not in other animals. In addition, some strains from pigs, chimpanzees and rodents show close sequence
Claude Kwe Yinda +7 more
doaj +1 more source
Impact of HIV infection and integrase strand transfer inhibitors-based treatment on the gut virome
Scientific Reports, 2022 Viruses are the most abundant components of the human gut microbiome with a significant impact on health and disease. The effects of human immunodeficiency virus (HIV) infection on gut virome has been scarcely analysed.
Pablo Villoslada-Blanco +12 more
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