Results 31 to 40 of about 18,538 (220)

Culture-independent detection and characterisation of Mycobacterium tuberculosis and M. africanum in sputum samples using shotgun metagenomics on a benchtop sequencer [PDF]

, 2014
Tuberculosis remains a major global health problem. Laboratory diagnostic methods that allow effective, early detection of cases are central to management of tuberculosis in the individual patient and in the community.
Emma L. Doughty, Martin Antonio, Sergeant, Martin J, Pallen, Mark J, Pallen, Mark J., Emma L Doughty, Ifedayo M.O Adetifa, Mark J. Pallen, Martin J. Sergeant, Doughty, Emma L, Sergeant, Martin J., Ifedayo, Adetifa M. O., Ifedayo Adetifa, Martin J Sergeant, Doughty, Emma L., Antonio, Martin, Adetifa, Ifedayo, Mark J Pallen   +17 more
core   +1 more source

Improved diagnosis of viral encephalitis in adult and pediatric hematological patients using viral metagenomics [PDF]

, 2020
Metagenomic sequencing is a powerful technique that enables detection of the full spectrum of pathogens present in any specimen in a single test. Hence, metagenomics is increasingly being applied for detection of viruses in clinical cases with suspected ...
Claas, E.C.J., Sidorov, I.A., Vries, J.J.C. de, Borne, P.A. von dem, Verschuuren, J.J.G.M., Karelioti, E., Carbo, E.C., Buddingh, E.P., Kroes, A.C.M., Feltkamp, M.C.W.   +9 more
core   +2 more sources

Viral metagenomics and blood safety

Transfusion Clinique et Biologique, 2016
The characterization of the human blood-associated viral community (also called blood virome) is essential for epidemiological surveillance and to anticipate new potential threats for blood transfusion safety. Currently, the risk of blood-borne agent transmission of well-known viruses (HBV, HCV, HIV and HTLV) can be considered as under control in high ...
Sauvage, V., Eloit, M.
openaire   +2 more sources

Tales from the crypt and coral reef: the successes and challenges of identifying new herpesviruses using metagenomics. [PDF]

, 2015
Herpesviruses are ubiquitous double-stranded DNA viruses infecting many animals, with the capacity to cause disease in both immunocompetent and immunocompromised hosts.
Charlotte J. Houldcroft, Houldcroft, CJ, Breuer, J, Judith Breuer   +3 more
core   +2 more sources

Metagenomics in Virology [PDF]

, 2021
Metagenomics, i.e., the sequencing and analysis of genomic information extracted directly from clinical or environmental samples, has become a fundamental tool to explore the viral world. Against the background of an extensive viral diversity revealed by
Matthijnssens, Jelle, Jelle Matthijnssens, Dutilh, Bas E, Simon Roux, Bas E. Dutilh, Roux, Simon   +5 more
core   +1 more source

Comparison with other viral metagenomics data sets. [PDF]

, 2013
Comparison with other viral metagenomics data sets.
David J. Spiro (52457), Ryan Kuzmickas (41917), Appolinaire Djikeng (41915), Norman G. Anderson (370218)   +3 more
core   +1 more source

Comparing Viral Metagenomic Extraction Methods [PDF]

Current Issues in Molecular Biology, 2017
A crucial step in the molecular detection of viruses in clinical specimens is the efficient extraction of viral nucleic acids. The total yield of viral nucleic acid from a clinical specimen is dependent on the specimen's volume, the initial virus concentration and the effectiveness provided by the extraction method.
Jeanette, Klenner, Claudia, Kohl, Piotr Wojtek, Dabrowski, Andreas, Nitsche   +3 more
openaire   +2 more sources

Assembly of viral genomes from metagenomes [PDF]

Frontiers in Microbiology, 2014
Viral infections remain a serious global health issue. Metagenomic approaches are increasingly used in the detection of novel viral pathogens but also to generate complete genomes of uncultivated viruses. In silico identification of complete viral genomes from sequence data would allow rapid phylogenetic characterization of these new viruses.
Saskia L Smits, Saskia L Smits, Rogier eBodewes, Aritz eRuiz-Gonzalez, Aritz eRuiz-Gonzalez, Aritz eRuiz-Gonzalez, Wolfgang eBaumgärtner, Marion P Koopmans, Marion P Koopmans, Albert D. M. E Osterhaus, Albert D. M. E Osterhaus, Anita C Schürch   +11 more
openaire   +5 more sources

Comparative Viral Metagenomics of Environmental Samples from Korea [PDF]

, 2013
The introduction of metagenomics into the field of virology has facilitated the exploration of viral communities in various natural habitats. Understanding the viral ecology of a variety of sample types throughout the biosphere is important per se, but ...
Tae Woong Whon, Jin-Woo Bae, Min-Soo Kim
core   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source