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Viral security proteins: counteracting host defences

Nature Reviews Microbiology, 2010
Vadim Agol, Anatoly P Gmyl
exaly  

Oligomerization of parvovirus B19 nonstructural protein (NS)1 is essentially for viral replication

Parvovirus B19 is a relevant human pathogen whose genome is replicated in the cell nucleus by cellular and viral encoded proteins. Non-structural protein 1 (NS1) has an important role in the process, responsible for nicking and unwinding of the viral genome, as mediated by an N-terminal endonuclease and a central SF3 helicase domain, respectively.
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