Results 71 to 80 of about 84,952 (272)

Easy and Rapid Detection of Mumps Virus by Live Fluorescent Visualization of Virus-Infected Cells. [PDF]

open access: yesPLoS ONE, 2015
Mumps viruses show diverse cytopathic effects (CPEs) of infected cells and viral plaque formation (no CPE or no plaque formation in some cases) depending on the viral strain, highlighting the difficulty in mumps laboratory studies. In our previous study,
Tadanobu Takahashi   +13 more
doaj   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li   +13 more
wiley   +1 more source

Studies of the mixed lymphocyte reaction by the virus plaque assay [PDF]

open access: yes, 1975
The virus plaque assay has been developed as a tool for enumerating activated lymphocytes. In previous studies using mitogens it was found that the assay detects activated T- but not activated B-lymphocytes.
Kano, S   +8 more
core   +1 more source

Advanced Dental Composite Technology via Bisilanized Dual‐Action Nanofillers for Biofilm Control

open access: yesAdvanced Science, EarlyView.
A multimodal research strategy has led to the development of an innovative resin‐based composite (RBC) with dual antibacterial action. The S_CM‐RBC formula showed strong antibiofilm activity, excellent mechanical strength, and biosafety. It effectively controlled oral bacteria in prevention of caries recurrence, and maintained pulp health in a rat ...
Chenmin Yao   +11 more
wiley   +1 more source

Evaluation of ViroCyt® Virus Counter for Rapid Filovirus Quantitation

open access: yesViruses, 2015
Development and evaluation of medical countermeasures for diagnostics, vaccines, and therapeutics requires production of standardized, reproducible, and well characterized virus preparations. For filoviruses this includes plaque assay for quantitation of
Cynthia A. Rossi   +9 more
doaj   +3 more sources

Screening and verification of antiviral compounds against HSV-1 using a method based on a plaque inhibition assay

open access: yesBMC Infectious Diseases, 2023
Background Herpes simplex virus type 1 (HSV-1) infection is a common viral disease that mainly causes oral lesions, but can also cause genital lesions in some instances.
Yingxian Yin   +15 more
doaj   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

open access: yesAdvanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang   +9 more
wiley   +1 more source

Viabilidade de adenovírus humano recombinante e norovírus murino em água do mar em tanques de depuração de ostras [PDF]

open access: yes, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2014.A depuração de moluscos bivalves é um processo utilizado que resulta na expulsão
Garcia, Lucas Ariel Totaro
core  

Recoded DENV2 clones have small plaque phenotype and reduced replication efficiency.

open access: yes, 2023
(a) Genomic maps showing regions of the DENV2 genome recoded with silent mutations. (b) BHK-21 hamster kidney cells, Huh-7 human hepatocarcinoma cells, HepG2 hepatoma cells, and C6/36 Aedes mosquito cells were infected with wildtype or recoded DENV2 ...
Wei-Xin Chin (843752)   +15 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

open access: yesAdvanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang   +13 more
wiley   +1 more source

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