Results 91 to 100 of about 1,527,964 (244)

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Unveiling the viral escape: Quantification of microfloc-bound viruses in precoagulation and membrane filtration

Journal of Water and Health
The implementation of precoagulation before the physical removal process is expected to achieve a high virus removal rate. However, viruses may form small flocs and subsequently escape into the effluent during physical removal processes.
Midori Yasui, Hiroyuki Katayama
doaj   +1 more source

Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication

Virology Journal, 2017
Background The rapid rise and spread in dengue cases, together with the unavailability of safe vaccines and effective antiviral drugs, warrant the need to discover and develop novel anti-dengue treatments. In this study the antiviral activity of geraniin,
Siti Aisyah Abdul Ahmad, Uma D. Palanisamy, Bimo A. Tejo, Miaw Fang Chew, Hong Wai Tham, Sharifah Syed Hassan   +5 more
doaj   +1 more source

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Llama-Derived Single Domain Antibodies to Build Multivalent, Superpotent and Broadened Neutralizing Anti-Viral Molecules [PDF]

, 2011
For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Virus (
Schepens, B, Temperton, Nigel J., M. Koenders, C. Theo Verrips, Schillemans, J, Ibanez, Lorena Itatı, J. Melero, de Haard, HJ, Verrips, C. Theo, S. Van Gucht, C.T. Verrips, Michael Saunders, Bert Schepens, Temperton, Nigel J, Ibanez, Lorena, Koenders, M, Melero, Jose A., Schepens Bert, de Haard, Hans J, Vanlandschoot, P, Steven Van Gucht, Gonzalez-Pajuelo Maria, Van Gucht, S, Xavier Saelens, Vanlandschoot Peter, Anna Hultberg, B. Schepens, Gonzalez-Pajuelo, Maria, Schillemans Joris, Koenders, Mireille, Nigel J. Temperton, Saunders Michael, Melero José A., de Haard, Hans J., Schillemans, Joris, Ibañez Lorena Itatí, de Haard Hans J., Temperton Nigel J., Ibañez,, Lorena Itatí, H.J. de Haard, Robin A. Weiss, Hultberg, A, Schepens, Bert, C Theo Verrips, N.J. Temperton, Ibanez, LI, Van Gucht, Steven, Verrips, Theo, Maria Gonzalez-Pajuelo, L.I. Ibanez, Rosseels Valérie, José A Melero, Hans J de Haard, Mireille Koenders, Hultberg Anna, Weiss, RA, Saelens Xavier, Saunders, Michael, R.A. Weiss, Weiss Robin A., Saelens, Xavier, Hans J. de Haard, Lorena Itatí Ibañez, A. Hultberg, Gonzalez-Pajuelo, M, Weiss, Robin A., Saelens, X, Joris Schillemans, Verrips, CT, Peter Vanlandschoot, Van Gucht Steven, M. Saunders, Valérie Rosseels, V. Rosseels, Koenders Mireille, Robin A Weiss, P. Vanlandschoot, Rosseels, V, José A. Melero, Hultberg, Anna, M. Gonzalez-Pajuelo, Rosseels, Valerie, J. Schillemans, Ibañez, Lorena Itatí, Melero, Jose Antonio, Vanlandschoot, Peter, Weiss, Robin A, Saunders, M, Nigel J Temperton, X. Saelens, Melero, José A, Verrips C. Theo, Temperton, NJ, Melero, JA, Verrips, C Theo   +94 more
core   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Development of a Cell-Based Reporter Potency Assay for Live Virus Vaccines

Vaccines
The rapid development of potency assays is critical in the development of life-saving vaccines. The traditional plaque assay or fifty percent tissue culture infectious dose (TCID50) assay used to measure the potency of live virus vaccines is time ...
Dengyun Sun, Brian K. Meyer, Dhanvanthri S. Deevi, Asra Mirza, Li He, Ashley Gruber, Susan J. Abbondanzo, Noah A. Benton, Melissa C. Whiteman, Robert C. Capen, Kevin B. Gurney   +10 more
doaj   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

A simple protein-based surrogate neutralization assay for SARS-CoV-2

JCI Insight, 2020
Most of the patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mount a humoral immune response to the virus within a few weeks of infection, but the duration of this response and how it correlates with clinical outcomes ...
Kento T. Abe, Zhijie Li, Reuben Samson, Payman Samavarchi-Tehrani, Emelissa J. Valcourt, Heidi Wood, Patrick Budylowski, Alan P. Dupuis II, Roxie C. Girardin, Bhavisha Rathod, Jenny H. Wang, Miriam Barrios-Rodiles, Karen Colwill, Allison J. McGeer, Samira Mubareka, Jennifer L. Gommerman, Yves Durocher, Mario Ostrowski, Kathleen A. McDonough, Michael A. Drebot, Steven J. Drews, James M. Rini, Anne-Claude Gingras   +22 more
doaj   +1 more source