Results 81 to 90 of about 84,952 (272)

Viral infection in Chitin Synthase-silenced insects.

, 2023
A) Dengue 2 titers in midguts 7 days postinfection. Viral titers were assessed by the plaque assay. Each dot represents an individual mosquito gut, and bars indicate the median. * p (TIF)
Carolina Barillas-Mury (150485), Patricia H. Alvarenga (14609756), Gabriela O. Paiva-Silva (14609759), Asher M. Kantor (4479313), Octavio A. C. Talyuli (4285141), Pedro L. Oliveira (10035698), Jose Henrique M. Oliveira (14609753), Vanessa Bottino-Rojas (783404), Gilbert O. Silveira (7376819), Ana Beatriz F. Barletta (8339190)   +9 more
core   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Métodos Para a Análise da Estabilidade e Infecciosidade da Cepa Vacinal de Rotavírus A em Diferentes Matrizes Aquáticas e Tempos de Estocagem [PDF]

, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.Os Rotavírus (RVA) estão envolvidos com muitos surtos de diarreia em crianças menores de 5 anos de idade, principalmente devido às más condições sanitárias ...
Damazo, Natália Alzira
core  

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

A weakly supervised framework for automated biological assay assessment. [PDF]

Virus Res
The quantification of biological assays, such as plaque and microbial assays is essential in virology and microbiology research. However, low-contrast images of stain-free samples are difficult to segment accurately and manual labeling is time-consuming.
Jiang H, Guo Q, Zhi X, Li H, Chen Y.
europepmc   +2 more sources

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Aplicação de métodos moleculares e de cultivo celular no monitoramento de vírus entéricos no ambiente aquático [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2009.Os vírus entéricos humanos são importantes causas de enfermidades veiculadas através da água.
Borges, Caroline Rigotto
core  

Ethacridine bocks SARS-CoV-2 by inactivating viral particles.

, 2021
(a) Upper panel: schematic showing the experimental design for plaque assay and qRT-PCR. The virus was pre-incubated with ethacridine or DMSO for 1 hr. The mixture was added to Vero cells for adsorption at 37°C for 1 hr. Details can be found in the text.
Raul Andino (17309), Xiaoquan Li (4349599), Peter V. Lidsky (11442581), Jayakar V. Nayak (6254378), Tsuguhisa Nakayama (11384046), Yinghong Xiao (11384040), Chien-Ting Wu (8850275), Miguel Garcia-Knight (11384043), Junjiao Yang (464018), Xiaokun Shu (225659), Peter K. Jackson (10810423)   +10 more
core   +1 more source