Results 51 to 60 of about 82,571 (135)

A simple protein-based surrogate neutralization assay for SARS-CoV-2

JCI Insight, 2020
Most of the patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mount a humoral immune response to the virus within a few weeks of infection, but the duration of this response and how it correlates with clinical outcomes ...
Kento T. Abe, Zhijie Li, Reuben Samson, Payman Samavarchi-Tehrani, Emelissa J. Valcourt, Heidi Wood, Patrick Budylowski, Alan P. Dupuis II, Roxie C. Girardin, Bhavisha Rathod, Jenny H. Wang, Miriam Barrios-Rodiles, Karen Colwill, Allison J. McGeer, Samira Mubareka, Jennifer L. Gommerman, Yves Durocher, Mario Ostrowski, Kathleen A. McDonough, Michael A. Drebot, Steven J. Drews, James M. Rini, Anne-Claude Gingras   +22 more
doaj   +1 more source

A weakly supervised framework for automated biological assay assessment

Virus Research
The quantification of biological assays, such as plaque and microbial assays is essential in virology and microbiology research. However, low-contrast images of stain-free samples are difficult to segment accurately and manual labeling is time-consuming.
Hongru Jiang, Qianyu Guo, Xiao Zhi, Heng Li, Yao Chen   +4 more
doaj   +1 more source

Improved Zika virus plaque assay using Vero/TMPRSS2 cell line

Microbiology Spectrum
Plaque assay is the gold standard for the quantification of viable cytopathic viruses like Zika virus (ZIKV). Some strains of ZIKV produce plaques that are very difficult to accurately visualize and count on the commonly used Vero cell line.
Olukunle O. Oluwasemowo, Monica E. Graham, Deepa K. Murugesh, Monica K. Borucki   +3 more
doaj   +1 more source

CellVision: A deep learning based image analysis platform to accelerate immuno-plaque assay data processing for dengue vaccine development

SLAS Discovery
Accurately detecting patterns of interest across a large number of images presents a significant challenge in data analysis for high-throughput analytical assays.
Yi Wang, Michelle N. Ngo, Shubing Wang, Justin Jarrah, Hossein Salami, Carl Hofmann, Anjali Joshi, Daniel Skomski, John W. Loughney   +8 more
doaj   +1 more source

Synthesis, characterization, cytotoxicity, and antiviral activity of new coumarin analogues against coronavirus

Results in Chemistry
Coronaviruses have emerged as a global health challenge, with the recent outbreak of SARS-CoV-2 affecting more than 600 million individuals worldwide. While vaccination remains a central preventive approach, addressing SARS-CoV-2 involves antiviral drugs,
Mohammad Auwal Sa’ad, Manickam Ravichandran, Lalitha Pattabhiraman, Shivkanya Fuloria, Veerasamy Ravichandran, Faizul Fikri Mohd Yusop, Neeraj Kumar Fuloria   +6 more
doaj   +1 more source

Evaluation of the Ratio of Spot Tests and Plaque-Forming Activity Tests of Bacteriophages of Prevalent Pathogens

Эпидемиология и вакцинопрофилактика
Relevance. Obtaining clean lysis spots, with tolerable presence of individual colonies of secondary growth, in spot tests is a criterion for assessing the effectiveness of therapeutic bacteriophages.
I. M. Pchelin, D. V. Azarov, V. A. Dedik, D. A. Kushnirenko, B. I. Aslanov, A. E. Goncharov, D. A. Lioznov   +6 more
doaj   +1 more source

DIRECTED EVOLUTION OF AN ONCOLYTIC VESICULAR STOMATITIS VIRUS ADAPTED TO HUMAN MALIGNANT MENINGIOMA CELLS

Sabiad
Objectives: Recombinantly-engineered versions of the oncolytic virus VSV are currently under clinical investigation for the treatment of several different types of cancer.
Burak Gizem Göleş, Hülya Yazıcı, John N. Davis   +2 more
doaj   +1 more source

A single amino acid mutation in norovirus NS4 promotes viral spread. [PDF]

J Virol
Annaswamy Srinivas M, Orchard RC.
europepmc   +1 more source

Antiviral potential of black tea and blueberry extracts against monkeypox virus by targeting orthopoxvirus surface proteins. [PDF]

Curr Res Microb Sci
Sha Y, Li Y, Liu Y, Chen J, Hua C, Fu Y, Yuan X, Yan Y, Jin S, Li Y, Xia A, Wang Q, Wang Q, Chen Y, Zhang R, Jiang S, Ying J.   +16 more
europepmc   +1 more source

<i>Phellodendron amurense</i> Leaf Extract Inhibits Rhabdovirus Infection by Targeting Early Stages of Viral Entry. [PDF]

Pathogens
Kim SY, Lee TK, Choi TJ.
europepmc   +1 more source