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Viruses and viral proteins [PDF]
IUCrJ, 2014 For more than 30 years X-ray crystallography has been by far the most powerful approach for determining the structures of viruses and viral proteins at atomic resolution.
Nuria Verdaguer +2 more
doaj +5 more sources
Safe Functional Inference for Uncharacterized Viral Proteins [PDF]
, 2008 The explosive growth in the number of sequenced genomes has created a flood of protein sequences with unknown structure and function. A routine protocol for functional inference on an input query sequence is based on a database search for homologues ...
Michal Linial, Yaniv Loewenstein
core +4 more sources
Innovative Strategies for the Targeted Degradation of Viral Proteins: Paving the Way for Next-Generation Therapeutics [PDF]
PharmaceuticsBackground/Objectives: This review discusses the development and application of targeted protein degradation strategies, particularly focusing on the ubiquitin–proteasome pathway and PROteolysis-TArgeting Chimeras (PROTAC) technology, for antiviral ...
Alexander S. Sobolev +1 more
doaj +2 more sources
Evolutionary‐Distinct Viral Proteins Subvert Rice Broad‐Spectrum Antiviral Immunity Mediated by the RAV15‐MYC2 Module [PDF]
Advanced ScienceA variety of plant viruses employ different virulence strategies to achieve successful infection, resulting in abnormal plant development. However, the common pathogenicity of distinct viruses has rarely been studied.
Hehong Zhang +10 more
doaj +2 more sources
Membrane activity of viral proteins. [PDF]
Biophys Rev, 2023 COVID-19 infection, caused by the SARS-CoV-2 coronavirus, has led to the largest pandemic since the Spanish flu in 1918. In view of this, the development of vaccines and antiviral drugs that can stop the spread of this infection has become an acute issue. Currently, in the search for antiviral drugs against COVID-19, much attention is paid to the study
Denieva Z.
europepmc +3 more sources
Specific Deubiquitinating Enzymes Promote Host Restriction Factors Against HIV/SIV Viruses
Frontiers in Immunology, 2021 Hijacking host ubiquitin pathways is essential for the replication of diverse viruses. However, the role of deubiquitinating enzymes (DUBs) in the interplay between viruses and the host is poorly characterized. Here, we demonstrate that specific DUBs are
Wenying Gao +12 more
doaj +1 more source
IEEE Access, 2023 Automatic analysis of colocalizing biological structures in multi-channel fluorescence microscopy images is an important task to quantify and understand biological processes at high spatial-temporal resolution.
Christian Ritter +5 more
doaj +1 more source
Expansion of Viral Genomes with Viral Protein Genome Linked Copies
SSRN Electronic Journal, 2022 Virus protein-linked genome (VPg) proteins are required for replication. VPgs are duplicated in a subset of RNA viruses however their roles are not fully understood and the extent of viral genomes containing VPg copies has not been investigated in detail.
Reid, Warsaba +3 more
openaire +2 more sources
Viruses, 2021 To explore the sequence context-dependent nature of the human immunodeficiency virus type 1 (HIV-1) protease’s specificity and to provide a rationale for viral mutagenesis to study the potential role of the nucleocapsid (NC) processing in HIV-1 ...
János András Mótyán +3 more
doaj +1 more source