Results 91 to 100 of about 2,128,088 (408)

HSV-1 DNA Replication—Coordinated Regulation by Viral and Cellular Factors

Viruses, 2021
DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that is coordinated with the cellular DNA damage response, repair and recombination of the viral genome, and viral gene transcription.
Jessica E. Packard, Jill A. Dembowski
doaj   +1 more source

Soybean antiviral immunity conferred by dsRNase targets the viral replication complex

Nature Communications, 2019
Eukaryotic positive-strand RNA viruses replicate their genomes in membranous compartments formed in a host cell, which sequesters the dsRNA replication intermediate from antiviral immune surveillance.
K. Ishibashi, M. Saruta, Takehiko Shimizu, M. Shu, T. Anai, K. Komatsu, N. Yamada, Y. Katayose, M. Ishikawa, M. Ishimoto, A. Kaga   +10 more
semanticscholar   +1 more source

Epitranscriptomic regulation of viral replication

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2017
RNA plays central roles in biology and novel functions and regulation mechanisms are constantly emerging. To accomplish some of their functions within the cell, RNA molecules undergo hundreds of chemical modifications from which N6-methyladenosine (m6A), inosine (I), pseudouridine (ψ) and 5-methylcytosine (5mC) have been described in eukaryotic mRNA ...
Pereira-Montecinos, Camila, Valiente-Echeverría, Fernando, Soto Rifo, Ricardo   +2 more
openaire   +3 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Viral replication dynamics could critically modulate vaccine effectiveness and should be accounted for when assessing new SARS-CoV-2 variants [PDF]

arXiv, 2021
In this article, we propose a theory to explain the reduction in vaccine effectiveness (VE) against the Delta SARS-CoV-2 variant and decreasing VE over time reported in recent studies. Using a model illustration, we show that in-host viral replication dynamics and delays in immune response could play a key role in VE.
arxiv  

Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection [PDF]

, 2002
Although antiviral agents which block human immunodeficiency virus (HIV) replication can result in long-term suppression of viral loads to undetectable levels in plasma, long-term therapy fails to eradicate virus, which generally rebounds after a single ...
Clotet, B, Frost, SDW, Leigh Brown, AJ, Martinez-Picado, J, Ruiz, L   +4 more
core   +2 more sources

Architecture of viral replication factories

Oncotarget, 2015
Compartmentalization of intracellular membrane is a marked characteristic during the pathogenesis of many viruses, which provides a microenvironment for virus to evade the host RNA interference defense response on one hand, and confines various host factors as well as metabolites in a stable space so that they can act in concert to complete virus ...
Yongliang Zhang, Dawei Li, Xiuling Cao
openaire   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV

mBio
HIV-1 unspliced RNA serves two distinct functions during viral replication: it is packaged into particles as the viral genome, and it is translated to generate Gag/Gag-Pol polyproteins required for virus assembly. Recent studies have demonstrated that in
Saiful Islam, Frank Maldarelli, Olga A. Nikolaitchik, Zetao Cheng, Robert Gorelick, Maria A. Nikolaitchik, Vinay K. Pathak, Wei-Shau Hu   +7 more
doaj   +1 more source

The N-Terminal of Aquareovirus NS80 Is Required for Interacting with Viral Proteins and Viral Replication. [PDF]

PLoS ONE, 2016
Reovirus replication and assembly occurs within viral inclusion bodies that formed in specific intracellular compartments of cytoplasm in infected cells.
Jie Zhang, Hong Guo, Qingxiu Chen, Fuxian Zhang, Qin Fang   +4 more
doaj   +1 more source