Results 151 to 160 of about 2,155,361 (380)
A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape
Scientific Reports, 2017 HIV presents one of the highest evolutionary rates ever detected and combination antiretroviral therapy is needed to overcome the plasticity of the virus population and control viral replication.
R. Lebbink +6 more
semanticscholar +1 more source
Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β
Advanced Biology, EarlyView.This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer +8 more
wiley +1 more source
Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. [PDF]
, 2019 HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs joined by less understood linker regions.
Fernandes, Jason D +4 more
core +3 more sources
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
Advanced Functional Materials, EarlyView.This study introduces an extracorporeal hemoperfusion system incorporating porous microbeads embedded with autocatalytic ceria nanoparticles (CeNPs) for targeted reactive oxygen species (ROS) scavenging in septic shock. The blood‐compatible hemoperfusion cartridge demonstrated significant improvements in survival, hemodynamic stability, and organ ...
Pilseon Im +10 more
wiley +1 more source
Replicating and non-replicating viral vectors for vaccine development
Current Opinion in Biotechnology, 2007 Viral vectors provide a convenient means to deliver vaccine antigens to select target cells or tissues. A broad spectrum of replicating and non-replicating vectors is available. An appropriate choice for select applications will depend on the biology of the infectious agent targeted, as well as factors such as whether the vaccine is intended to prevent
openaire +2 more sources
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
Phytopathology ResearchViral proteins can aggregate into granules within host cells, known as viral factories, or viroplasms, which play a pivotal role in facilitating viral replication and shielding the viral genome from cellular defense mechanisms.
Zhiyi Wang +7 more
doaj +1 more source
REPLICATION OF VIRAL RNA, VI. NUCLEOTIDE COMPOSITION OF THE REPLICATIVE FORM OF TOBACCO MOSAIC VIRUS RNA AND OF ITS COMPONENT STRANDS [PDF]
, 1965 Charles Weissmann +4 more
openalex +1 more source
PLoS Pathogens, 2016 Hepatitis E virus (HEV) causes acute hepatitis in many parts of the world including Asia, Africa and Latin America. Though self-limiting in normal individuals, it results in ~30% mortality in infected pregnant women.
V. Nair +9 more
semanticscholar +1 more source