Results 251 to 260 of about 617,233 (366)

Herpesviruses mimic zygotic genome activation to promote viral replication. [PDF]

Nat Commun
Neugebauer E, Walter S, Tan J, Drayman N, Franke V, van Gent M, Pennisi S, Veratti P, Stein KS, Welker I, Tay S, Verjans GMGM, Timmers HTM, Akalin A, Landthaler M, Ensser A, Wyler E, Full F.   +17 more
europepmc   +1 more source

Trustworthy Inverse Molecular Design via Alignment with Molecular Dynamics

Advanced Science, EarlyView.
Data‐driven inverse molecular design (IMD) is a promising approach to discovering new molecules with desired properties. Despite the remarkable progress, existing IMD methods lag behind in terms of trustworthiness, as indicated by their misalignment with the ground‐truth function that models the molecular dynamics.
Kevin Tirta Wijaya, Navid Ansari, Hans‐Peter Seidel, Vahid Babaei   +3 more
wiley   +1 more source

Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA.

, 1986
Paul C. Zamecnik, John Goodchild, Y‐h. Taguchi, Prem S. Sarin   +3 more
openalex   +1 more source

Analysis of the earliest steps of hepadnavirus replication: genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity [PDF]

, 1993
Josef Köck, H J Schlicht
openalex   +1 more source

The whole genome analysis of the wild-type and attenuated orf virus reveals that ORF022 facilitates viral replication. [PDF]

BMC Genomics
Jing T, Wang Y, Bu Y, Chen X, Feng S, Liu W, Niyazbekova Z, Chen D, Gao X, Ma W.   +9 more
europepmc   +1 more source

Adducin‐1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity

Advanced Science, EarlyView.
In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang, Jiahui Zou, Yaoming Jin, Chenjun Jiang, Shaoyu Tu, Tong Chen, Jinli Guo, Yanqing Cheng, Meilin Jin, Huanchun Chen, Hongbo Zhou   +10 more
wiley   +1 more source

Conserved cysteine and histidine residues of the avian myeloblastosis virus nucleocapsid protein are essential for viral replication but are not "zinc-binding fingers".

, 1988
Joyce E. Jentoft, L Smith, Xiangdong Fu, Martin R. Johnson, Jonathan Leis   +4 more
openalex   +1 more source

The vpx gene of simian immunodeficiency virus facilitates efficient viral replication in fresh lymphocytes and macrophage [PDF]

, 1991
Xiaotian Yu, Q C Yu, Max Essex, T H Lee
openalex   +1 more source

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication. [PDF]

Adv Sci (Weinh)
He H, Yuan K, Pan J, Weng S, Li C, Chen Y, He J.   +6 more
europepmc   +1 more source

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

Advanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li, Fang Ye, Yucheng Zheng, Jie Wang, Haoran Peng, Lili Zhu, Lili Chen, Tao Yu, Huan Ge, Jiaqi He, Binghao Zhang, Jiayun Wu, Zhiyi Zhang, Liangliang Jiang, Geng Chen, Ping Zhao, Ke Lan, Zhenjiang Zhao, Xuhong Qian, Ke Xu, Yang Du, Honglin Li   +21 more
wiley   +1 more source