Results 281 to 290 of about 2,261,873 (405)

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Interaction of West Nile virus NS5 with orthoflavivirus SLA RNAs and their effects on viral replication and inhibition. [PDF]

J Virol
Feinberg MA, Le MT, Carpio KL, Knyazhanskaya E, Barrett ADT, Choi KH.   +5 more
europepmc   +1 more source

Human and Simian Immunodeficiency Virus Capsid Proteins Are Major Viral Determinants of Early, Postentry Replication Blocks in Simian Cells

, 2002
Christopher M. Owens, Peter Yang, Heinrich G. Göttlinger, Joseph Sodroski   +3 more
openalex   +1 more source

Structural Basis for Membrane Anchorage of Viral ϕ29 DNA during Replication [PDF]

, 2005
Armando Albert, Daniel Muñoz‐Espín, Marta de los Reyes Jiménez, Juan Luis Asensio, J.A. Hermoso, Margarita Salas, Wilfried J. J. Meijer   +6 more
openalex   +1 more source

Reverse Genetics System Demonstrates that Rotavirus Nonstructural Protein NSP6 Is Not Essential for Viral Replication in Cell Culture

Journal of Virology, 2017
S. Komoto, Y. Kanai, Saori Fukuda, M. Kugita, Takahiro Kawagishi, N. Ito, M. Sugiyama, Y. Matsuura, Takeshi Kobayashi, K. Taniguchi   +9 more
semanticscholar   +1 more source

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, EarlyView.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

A conserved RNA structure at the capsid-coding sequence of Zika virus genome is required for viral replication in a host-dependent manner. [PDF]

J Virol
Costa Navarro GS, Pallarés HM, González López Ledesma MM, de Borba L, Mazzolenis R, Gamarnik AV.   +5 more
europepmc   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

Deciphering pUL10's mastery in duck plague virus virulence: dual coordination of host immunity and viral replication. [PDF]

Poult Sci
Li C, Wang M, Cheng A.
europepmc   +1 more source

Plum Pox Virus 6K1 Protein Is Required for Viral Replication and Targets the Viral Replication Complex at the Early Stage of Infection

Journal of Virology, 2016
H. Cui, Aiming Wang
semanticscholar   +1 more source