Results 121 to 130 of about 145,951 (305)

Towards Modeling HIV Long Term Behavior

, 2011
The precise mechanism that causes HIV infection to progress to AIDS is still unknown. This paper presents a mathematical model which is able to predict the entire trajectory of the HIV/AIDS dynamics, then a possible explanation for this progression is ...
Hernandez-Vargas, Esteban A., Mehta, Dhagash, Middleton, Richard H.   +2 more
core   +1 more source

Plant phenology supports the multi-emergence hypothesis for ebola spillover events [PDF]

, 2017
Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored.
Douglas, Noah E., Isokpehi, Raphael D., Johnson, Brianna, McGill, Ayana, Sivasundaram, Seenith, Wollenberg Valero, Katharina C., Wootson, Kiara   +6 more
core   +1 more source

Programmable Klebsiella pneumoniae Phage Tropism Enabled by Scalable Receptor‐Binding Protein Mining and Modular Assembly

Advanced Science, EarlyView.
This work introduces a scalable, data‐driven strategy that turns the vast sequence diversity of phage receptor‐binding proteins into modular tools for engineering customizable phages. By clustering and experimentally validating diverse RBPs, the authors build an accurate map linking sequence to host specificity and create plug‐and‐play modules that ...
Shisong Jing, Yiyao Song, Xianbiao Bi, Yuqin Song, Dawei Wei, Jiangqing Huang, Yuan Zeng, Gang Zhang, Rong Zhang, Chao Wang, Jie Feng   +10 more
wiley   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Different polarization and functionality of CD4+ T helper subsets in people with post-COVID condition

Frontiers in Immunology
IntroductionAfter mild COVID-19 that does not require hospitalization, some individuals develop persistent symptoms that may worsen over time, producing a multisystemic condition termed Post-COVID condition (PCC).
Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Clara Sánchez-Menéndez, Olivia de la Calle-Jiménez, Olivia de la Calle-Jiménez, Olivia de la Calle-Jiménez, Elena Mateos, Elena Mateos, Lorena Vigón, Daniel Fuertes, María Aranzazu Murciano Antón, María Aranzazu Murciano Antón, Esther San José, Valentín García-Gutiérrez, Miguel Cervero, Montserrat Torres, Montserrat Torres, Mayte Coiras, Mayte Coiras   +18 more
doaj   +1 more source

A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4⁺ T cells as a Major Niche for HIV-1 Transcription in HIV-Infected Patients

mBio, 2017
Cells that actively transcribe HIV-1 have been defined as the “active viral reservoir” in HIV-infected individuals. However, important technical limitations have precluded the characterization of this specific viral reservoir during both treated and ...
Judith Grau-Expósito, Carla Serra-Peinado, Lucia Miguel, Jordi Navarro, Adrià Curran, Joaquin Burgos, Imma Ocaña, Esteban Ribera, Ariadna Torrella, Bibiana Planas, Rosa Badía, Josep Castellví, Vicenç Falcó, Manuel Crespo, Maria J. Buzon   +14 more
doaj   +1 more source

Phenotyping Viral Reservoirs to Reveal HIV-1 Hiding Places

Current HIV/AIDS Reports
Abstract Purpose of Review Despite suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist in various cell types and tissues and reignite active replication if therapy is stopped. Persistence of the viral reservoirs in people with HIV-1 (PWH) is the main obstacle to achieving a cure.
Chen, Wenxuan, Berkhout, Ben, Pasternak, Alexander O.   +2 more
openaire   +3 more sources

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

The X awakens: multifactorial ramifications of sex-specific differences in HIV-1 infection

Journal of Virus Eradication, 2016
Sex-specific differences have been described for a variety of infectious and autoimmune diseases. In HIV-1 infection women present with significantly lower viral loads during early infection, but during chronic infection women progress faster to AIDS for
Sven Hagen, Marcus Altfeld
doaj   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source