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Viral, inflammatory, and reservoir characteristics of posttreatment controllers
Current Opinion in HIV and AIDS, 2021Purpose of review To provide an overview of studies to date that have identified posttreatment controllers (PTCs) and to explore current evidence around clinical characteristics, immune effector function, and inflammatory and viral reservoir characteristics that may underlie the control mechanism.
McMahon, James +2 more
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Bats as Reservoirs of Viral Zoonoses
2021In the last few decades, a special interest in viruses hosted by bats arose after links with zoonoses of public health importance emerged. A dramatic increase in documented viral diversity in bats has occurred with an increasing difficulty in interpretation of results and risk assessments.
Sonia Cheetham, Wanda Markotter
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Annual Review of Virology, 2016
Bats are hosts of a range of viruses, including ebolaviruses, and many important human viral infections, such as measles and mumps, may have their ancestry traced back to bats. Here, I review viruses of all viral families detected in global bat populations.
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Bats are hosts of a range of viruses, including ebolaviruses, and many important human viral infections, such as measles and mumps, may have their ancestry traced back to bats. Here, I review viruses of all viral families detected in global bat populations.
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Viral reservoirs and HIV-specific immunity
Current Opinion in Internal Medicine, 2006HIV-1 infection is complicated by the presence of latently infected CD4 T cells as well as several anatomical reservoirs that present a barrier to eradication by current antiretroviral therapy. The early establishment of these reservoirs also presents a challenge to the development of preventive vaccines.
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Quantitation of integrated proviral DNA in viral reservoirs
Current Opinion in HIV and AIDS, 2013Integrated HIV DNA can give rise to infectious virus, and therefore may be a surrogate of reservoir size. How this form reflects the amount of replication competent virus in vivo remains to be established. This review highlights the technical hurdles involved in measuring integrated HIV DNA, progress toward overcoming these hurdles by repetitive ...
Erin H, Graf, Una, O'Doherty
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The Challenge of Viral Reservoirs in HIV-1 Infection
Annual Review of Medicine, 2002▪ Abstract A viral reservoir is a cell type or anatomical site in association with which a replication-competent form of the virus accumulates and persists with more stable kinetic properties than the main pool of actively replicating virus. This article reviews several cell types and anatomical sites proposed as potential reservoirs for HIV-1.
Joel N, Blankson +2 more
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Non-invasive nuclear imaging for localization of viral reservoirs
Nature Methods, 2015Antibody-targeted positron emission tomography (immunoPET) can visualize sites of HIV replication that are difficult to access by traditional means such as tissue biopsies.
Ekaterina, Dadachova, Joan W, Berman
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AIDS, 2012
Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved.
Tae-Wook, Chun, Anthony S, Fauci
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Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved.
Tae-Wook, Chun, Anthony S, Fauci
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Attacking the HIV Reservoir from the Immune and Viral Perspective
Current HIV/AIDS Reports, 2012Upon HIV infection, a subset of latently infected cells carrying transcriptionally inactive integrated proviral DNA (the HIV-1 reservoir) is rapidly established. These cells are the main force behind HIV persistence under highly active antiretroviral therapy (HAART), which only impacts on actively replicating viruses and it is therefore unable to ...
Massanella, Marta +2 more
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