Results 21 to 30 of about 246,650 (312)
A viral-human interactome based on structural motif-domain interactions captures the human infectome. [PDF]
PLoS ONE, 2013 Protein interactions between a pathogen and its host are fundamental in the establishment of the pathogen and underline the infection mechanism. In the present work, we developed a single predictive model for building a host-viral interactome based on ...
Aldo Segura-Cabrera +3 more
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Viruses, 2018 Chikungunya virus (CHIKV) has re-emerged as one of the many medically important arboviruses that have spread rampantly across the world in the past decade.
Kai Zhi Wong, Justin Jang Hann Chu
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Structural characterization of viral fusion proteins [PDF]
Current Biology, 1995 Infection by enveloped viruses is initiated by the fusion of viral and cellular membranes. In many cases, the viral membrane proteins that mediate fusion must undergo conformational changes to become active. Influenza hemagglutinin, for example, is activated by a dramatic conformational rearrangement, triggered by the low pH of the intracellular ...
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Illuminating structural proteins in viral “dark matter” with metaproteomics [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Marine viruses are abundant and have substantial ecosystem impacts, yet their study is hampered by the dominance of unannotated viral genes. Here, we use metaproteomics and metagenomics to examine virion-associated proteins in marine viral communities, providing tentative functions for 677,000 viral genomic sequences and the ...
Brum, Jennifer R +8 more
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Non-structural proteins of bovine viral diarrhea virus
Virus Genes, 2022 Bovine viral diarrhea virus (BVDV) belongs to the family Flaviviridae genus pestivirus. The viral genome is a single-stranded, positive-sense RNA that encodes four structural proteins (i.e., C, Erns, E1, and E2) and eight non-structural proteins (NSPs) (i.e., Npro, p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B). Cattle infected with BVDV exhibit a number of
Shanshan Chi +5 more
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Superimposition of Viral Protein Structures: A Means to Decipher the Phylogenies of Viruses [PDF]
Viruses, 2020 Superimposition of protein structures is key in unravelling structural homology across proteins whose sequence similarity is lost. Structural comparison provides insights into protein function and evolution. Here, we review some of the original findings and thoughts that have led to the current established structure-based phylogeny of viruses: starting
Janne J. Ravantti +3 more
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LLOVIU VIRUS - A NOVEL FILOVIRUS, ENDEMIC IN EUROPE
Вопросы вирусологии, 2018 The data on a recently revealed novel filovirus (Lloviu virus, family Filoviridae, genera Cuevavirus) in Europe are viewed in this issue. The molecular-biological properties of genome fragments of Lloviu virus were isolated from perished bats ...
T. E. Sizikova +3 more
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POLM inhibits porcine epidemic diarrhea virus replication by degrading multiple viral structural proteins [PDF]
J VirolXinyu Cao +10 more
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Microbiology Spectrum, 2023 The pathogenicity of a virus to a specific host species is an inerratic and describable ability of a virus to cause infection but is generally shaped by a variety of abiotic and biotic factors.
Huan Yu +6 more
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Keeping It Together: Structures, Functions, and Applications of Viral Decoration Proteins [PDF]
Viruses, 2020 Decoration proteins are viral accessory gene products that adorn the surfaces of some phages and viral capsids, particularly tailed dsDNA phages. These proteins often play a “cementing” role, reinforcing capsids against accumulating internal pressure due to genome packaging, or environmental insults such as extremes of temperature or pH.
Corynne L. Dedeo +2 more
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