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Treatment of Respiratory Viral Coinfections [PDF]

open access: yesEpidemiologia, 2022
With the advent of rapid multiplex PCR, physicians have been able to test for multiple viral pathogens when a patient presents with influenza-like illness.
Paul Alexander, Hana M. Dobrovolny
doaj   +3 more sources

Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2

open access: yesFrontiers in Immunology, 2022
The scale of the COVID-19 pandemic forced urgent measures for the development of new therapeutics. One of these strategies is the use of convalescent plasma (CP) as a conventional source for passive immunity.
Neslihan Pakize Taşlı   +39 more
doaj   +1 more source

Infectious spleen and kidney necrosis virus induces the reactive oxidative species/Nrf2-mediated oxidative stress response for the regulation of mitochondrion-mediated Bax/Bak cell death signals in GF-1 cells

open access: yesFrontiers in Microbiology, 2022
Infectious spleen and kidney necrosis virus (ISKNV) infections can trigger host cell death and are correlated with viral replication; however, they have rarely been considered in terms of the host organelle involvement.
Pin-Han Chen   +5 more
doaj   +1 more source

The ASSESSMENT OF THE KNOWLEDGE AND ATTITUDE TOWARDS ANTIBIOTIC RESISTANCE AMONG PEOPLE RESIDING IN NAMUWONGO, MAKINDYE EAST DIVISION KAMPALA, UGANDA, A DESCRIPTIVE CROSS-SECTIONAL STUDY.

open access: yesStudent's Journal of Health Research Africa, 2023
Background: There is an increasing global concern about Antibiotic resistance causing a serious threat to public health with estimated 700,000 deaths per year and it’s estimated to increase to about 10 million deaths by 2050.
daniel safari   +4 more
doaj   +1 more source

Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents

open access: yesFrontiers in Cell and Developmental Biology, 2022
Metabotropic glutamate receptor subtype 5 (mGluR5) is a G-protein-coupled receptor found widely in the central nervous system. It has been involved in the development and progression of some neurodegenerative diseases, but its role in prion diseases is ...
Chao Hu   +19 more
doaj   +1 more source

Synthetic Peptides as a Promising Alternative to Control Viral Infections in Atlantic Salmon

open access: yesPathogens, 2020
Viral infections in salmonids represent an ongoing challenge for the aquaculture industry. Two RNA viruses, the infectious pancreatic necrosis virus (IPNV) and the infectious salmon anemia virus (ISAV), have become a latent risk without healing therapies
Constanza Cárdenas   +6 more
doaj   +1 more source

Characteristics of Chinese patients with genetic CJD who have E196A or E196K mutation in PRNP: comparative analysis of patients identified in the Chinese National CJD Surveillance System

open access: yesBMJ Open, 2021
Objective Two different mutations at codon 196, namely E196A and E196K, have been reported to be related to genetic Creutzfeldt-Jakob disease (CJD). We aimed to comparatively analyse the features of Chinese patients with these two mutations from the CJD ...
Wei Zhou   +9 more
doaj   +1 more source

Case report for human infection with a highly pathogenic avian influenza A(H5N6) virus in Beijing, China 2019

open access: yesBiosafety and Health, 2020
Bird infections with highly pathogenic avian influenza A(H5N6) viruses have been identified since 2014. With very limited occasion, the virus could sporadically spilled over to infect humans.
Lei Yang   +6 more
doaj   +1 more source

Contribution of hypoxia inducible factor-1 during viral infections

open access: yesVirulence, 2020
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs ...
Antonia Reyes   +5 more
doaj   +1 more source

Impact of COVID-19 Pandemic on Patients With Neurodegenerative Diseases

open access: yesFrontiers in Aging Neuroscience, 2021
COVID-19 pandemic has already produced great impacts on global health security and social-economy. Elderly, particularly those with underlying diseases, are suffering from higher fatality rate.
Chao Hu   +6 more
doaj   +1 more source

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