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Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]

, 2009
The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Nadine Müther, Nadja Noske, Anja Ehrhardt   +2 more
openalex   +7 more sources

Gene-Editing Technologies Paired With Viral Vectors for Translational Research Into Neurodegenerative Diseases [PDF]

Frontiers in Molecular Neuroscience, 2020
Diseases of the central nervous system (CNS) have historically been among the most difficult to treat using conventional pharmacological approaches.
Joseph Edward Rittiner, Joseph Edward Rittiner, Joseph Edward Rittiner, Malik Moncalvo, Malik Moncalvo, Malik Moncalvo, Ornit Chiba-Falek, Ornit Chiba-Falek, Boris Kantor, Boris Kantor, Boris Kantor   +10 more
doaj   +2 more sources

Incorporation of regulatory DNA elements within a viral vector improves recombinant protein expression in plants [PDF]

Sci Rep
Coates RJ, Scofield S, Young MT.
europepmc   +4 more sources

HIV-1 subtype diversity, phylogenetic analysis and study of drug resistance in strains circulating in the Ural Federal District

Журнал микробиологии, эпидемиологии и иммунобиологии, 2022
Introduction. Ural Federal District (UFD) has been one of the most HIV-affected areas in the Russian Federation during past 20 years. The total number of people living with HIV/AIDS (PLWH) and receiving antiretroviral therapy (ART) exceeds 100,000 (61.7%
M. V. Piterskiy, A. G. Gusev, O. A. Khodakov, Yu. A. Zakharova, A. V. Semenov   +4 more
doaj   +1 more source

Characterisation of new animal cell cultures’ sensitivity to Coxsackievirus B5 and Herpes simplex virus‑1

Биопрепараты: Профилактика, диагностика, лечение, 2023
The increase in the number of cell cultures for virology and biotechnology enhances the chances of a successful response to threats related to outbreaks of well-known and new human infectious diseases.
Yu. A. Zakharova, A. V. Ostapchuk, W. W. Wasielewski, O. S. Fedotova, N. A. Shmeleva   +4 more
doaj   +1 more source

Assessment of Seroprevalence to SARS-CoV-2 in Various Population Cohorts Using Logit Regression Models During Initial Period of Herd Immunity Formation

Проблемы особо опасных инфекций, 2022
The aim of the study was to assess the dynamics of seroprevalence to SARS-CoV-2 in various population groups during the initial period of herd immunity formation based on multivariate analysis using logit regression models.Materials and methods.
V. A. Mishchenko, M. V. Pitersky, Т. A. Platonova, S. S. Smirnova, I. V. Vyalykh, I. P. Bykov, L. G. Vyatkina, T. V. Makhorina, A. M. Orlov, N. G. Popkova, A. V. Semenov   +10 more
doaj   +1 more source

To the question of the relevance of the development and prospects for the use of the bacteriophage Streptococcus pneumoniae

Журнал микробиологии, эпидемиологии и иммунобиологии, 2022
Introduction. The prevalence of Streptococcus pneumoniae strains causing invasive forms of pneumococcal infection and the growing rates of antibiotic resistance of individual serotypes of the pathogen pose a number of urgent and socially significant ...
Yuliya A. Zakharova, Ivan A. Ivashchenko, Ekaterina V. Bolgarova   +2 more
doaj   +1 more source

Phenotypic profile of priority multiresistant Аcinetobacter baumannii sequence types (ST 1167, ST 944, ST 208)

Журнал микробиологии, эпидемиологии и иммунобиологии, 2022
Introduction. About 1,000,000 cases of infections caused by Acinetobacter spp. per year are registered globally, making up 1.8% of all the cases of hospital-acquired infections.
O. S. Fedotova, Yu. A. Zakharova, A. V. Ostapchuk, U. A. Bazhanova, A. A. Zakharov   +4 more
doaj   +1 more source

Monitoring of Dengue Virus in Field-caught Aedes Species (Diptera: Culicidae) by Molecular Method, from 2016 to 2017 in Southern Iran [PDF]

Journal of Health Sciences and Surveillance System, 2023
Background: Aedes mosquitoes transmit important arboviral diseases such as dengue to humans. This study was conducted to determine dengue virus infection in Aedes mosquitoes, emphasizing Aedes aegypti by Reverse Transcriptase-Polymerase Chain Reaction ...
Kourosh Azizi, Hedayat Dorzaban, Aboozar Soltani, Hamzeh Alipour, Seyed Aghil Jaberhashemi, Mostafa Salehi-Vaziri, Tahereh Mohammadi, Zahra Fereydouni, Azim Paksa   +8 more
doaj   +1 more source

Purulent-septic infections in puerperas. Part 1. Рrevalence, risk factors, epidemiological surveillance (literature review)

Журнал микробиологии, эпидемиологии и иммунобиологии, 2022
Purulent-septic infections (PSI) of puerperas are one of the leading medical and social problems of modern health care. A significant prevalence, an upward trend, insufficient completeness of their identification and registration, along with a high ...
S. S. Smirnova, I. A. Egorov, A. A. Golubkova   +2 more
doaj   +1 more source