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Possible Mechanisms of mRNA-LNP Degradation: A Comprehensive Review
VaccinesMessenger RNA-lipid nanoparticle (mRNA-LNP)-based drug products represent a promising platform for prophylactic and therapeutic applications. However, their limited stability poses significant challenges for storage and global distribution.
MD Faizul Hussain Khan +3 more
doaj +1 more source
Viral vector‐based cancer treatment and current clinical applications
MedComm – Oncology, 2023 Owing to the limitations of conventional cancer therapies, including chemotherapy, radiotherapy, and surgery, gene therapy has become a prominent strategy for cancer treatment over the past few decades.
Lingwan Xie +6 more
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Tropism-modification strategies for targeted gene delivery using adenoviral vectors [PDF]
, 2010 Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ...
Coughlan, L. +20 more
core +1 more source
Innate Immune Response to Viral Vectors in Gene Therapy
, 2023 Viral vectors play a pivotal role in the field of gene therapy, with several related drugs having already gained clinical approval from the EMA and FDA.
Yixuan Wang, Wenwei Shao
core +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Freeze-Drying of mRNA-LNPs Vaccines: A Review
VaccinesThe instability of mRNA vaccines presents significant challenges for their storage, transportation, and large-scale distribution, particularly in resource-limited countries.
MD Faizul Hussain Khan +3 more
doaj +1 more source
Viral Vectors in Gene Therapy: Where Do We Stand in 2023?
, 2023 Viral vectors have been used for a broad spectrum of gene therapy for both acute and chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor, toxic, suicide and immunostimulatory genes, such as cytokines and ...
Kenneth Lundstrom
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Generation of enhanced gene delivery vectors by directed evolution of adeno-associated virus [PDF]
, 2006 Despite promising advance in the development of viral vectors based on AAV for human gene therapy, several major hurdles for a more general use remain.
Endell, Jan
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Recent advances in the development of gene delivery systems
Biomaterials Research, 2019 Background Gene delivery systems are essentially necessary for the gene therapy of human genetic diseases. Gene therapy is the unique way that is able to use the adjustable gene to cure any disease.
YK Sung, SW Kim
doaj +1 more source