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Diseases, 2018 Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine.
Kenneth Lundstrom
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Novel Viral Vectors for Gene Therapy
VirusesViral vectors are gene transfer tools assembled from the backbones of naturally occurring viruses [...]
Ottmar Herchenröder +1 more
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Recent Advances in miRNA Delivery Systems
Methods and Protocols, 2021 MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that are produced in a tissue and time-specific manner to orchestrate gene expression post-transcription.
Ishani Dasgupta, Anushila Chatterjee
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Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]
, 2009 The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Anja Ehrhardt +6 more
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Progress in the use of adeno-associated viral vectors for gene therapy [PDF]
, 2004 The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Markus Braun-Falco +7 more
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Vaccines, 2020 Developing vaccine technology platforms to respond to pandemic threats or zoonotic diseases is a worldwide high priority. The risk of infectious diseases transmitted from wildlife and domestic animals to humans makes veterinary vaccination and animal ...
Omar Farnós +7 more
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Generation of cell lines to complement Adenovirus vectors using recombination-mediated cassette exchange [PDF]
, 2010 Background Adenovirus serotype 5 (Ad5) has many favourable characteristics for development as a gene therapy vector. However, the utility of current Ad5 vectors is limited by transient transgene expression, toxicity and immunogenicity.
Farley, Daniel C. +8 more
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Gene Therapy, Early Promises, Subsequent Problems, and Recent Breakthroughs [PDF]
Advanced Pharmaceutical Bulletin, 2013 Gene therapy is one of the most attractive fields in medicine. The concept of gene delivery to tissues for clinical applications has been discussed around half a century, but scientist’s ability to manipulate genetic material via recombinant DNA ...
Saeideh Razi Soofiyani +4 more
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Nanosystems for gene therapy targeting brain damage caused by viral infections
Materials Today Bio, 2023 Several human pathogens can cause long-lasting neurological damage. Despite the increasing clinical knowledge about these conditions, most still lack efficient therapeutic interventions.
Talita Nascimento da Silva +7 more
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Molecular Therapy: Methods & Clinical Development, 2019 Despite numerous advancements in production protocols, manufacturing AAV to meet exceptionally high demand (1016–1017 viral genomes [VGs]) in late clinical stages and for eventual systemic delivery poses significant challenges.
Pranav R.H. Joshi +7 more
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