Viral and non-viral vectors in gene therapy: current state and clinical perspectives [PDF]
EBioMedicineSummary: Advancements in gene therapy have achieved significant milestones in treating human diseases, offering renewed hope to patients with limited options.
Guannan Geng +6 more
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Non-Viral Vectors for Delivery of Nucleic Acid Therapies for Cancer [PDF]
BioTech, 2022 The research and development of non-viral gene therapy has been extensive over the past decade and has received a big push thanks to the recent successful approval of non-viral nucleic acid therapy products.
Shrey Kanvinde +4 more
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Emerging non-viral vectors for gene delivery [PDF]
Journal of Nanobiotechnology, 2023 Gene therapy holds great promise for treating a multitude of inherited and acquired diseases by delivering functional genes, comprising DNA or RNA, into targeted cells or tissues to elicit manipulation of gene expression.
Chenfei Wang +8 more
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Non Viral Vectors in Gene Therapy- An Overview [PDF]
Journal of Clinical and Diagnostic Research, 2015 Non-viral vectors are simple in theory but complex in practice. Apart from intra cellular and extracellular barriers, number of other challenges also needs to be overcome in order to increase the effectiveness of non-viral gene transfer.
Murali Ramamoorth, Aparna Narvekar
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Nanotechnology-based non-viral vectors for gene delivery in cardiovascular diseases [PDF]
Frontiers in Bioengineering and BiotechnologyGene therapy is a technique that rectifies defective or abnormal genes by introducing exogenous genes into target cells to cure the disease. Although gene therapy has gained some accomplishment for the diagnosis and therapy of inherited or acquired ...
Liping Jiao +6 more
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Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy [PDF]
Molecules, 2021 Gene-directed enzyme prodrug therapy (GDEPT) has been intensively studied as a promising new strategy of prodrug delivery, with its main advantages being represented by an enhanced efficacy and a reduced off-target toxicity of the active drug.
Adriana Aurelia Chis +9 more
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A Quality by Design Approach in Pharmaceutical Development of Non-Viral Vectors with a Focus on miRNA [PDF]
Pharmaceutics, 2022 Cancer is the leading cause of death worldwide. Tumors consist of heterogeneous cell populations that have different biological properties. While conventional cancer therapy such as chemotherapy, radiotherapy, and surgery does not target cancer cells ...
Ioana Toma +4 more
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Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery [PDF]
Journal of Controlled Release, 2022 Shirui Mao, Hezhi Wang
exaly +2 more sources
Application of Non-Viral Vectors in Drug Delivery and Gene Therapy [PDF]
Polymers, 2021 Haixin Cui, Zhanghua Zeng, Changjiao Sun
exaly +2 more sources
How Far Are Non-Viral Vectors to Come of Age and Reach Clinical Translation in Gene Therapy? [PDF]
International Journal of Molecular Sciences, 2021 Myriam Sainz-Ramos +2 more
exaly +2 more sources