Results 21 to 30 of about 212,876 (206)
CRISPR/Cas systems: Delivery and application in gene therapy
Frontiers in Bioengineering and Biotechnology, 2022 The CRISPR/Cas systems in prokaryotes such as bacteria and archaea are the adaptive immune system to prevent infection from viruses, phages, or other foreign substances. When viruses or phages first invade the bacteria, Cas proteins recognize and cut the
Jie Huang +8 more
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Current Approaches for Glioma Gene Therapy and Virotherapy
Frontiers in Molecular Neuroscience, 2021 Glioblastoma (GBM) is the most common and aggressive primary brain tumor in the adult population and it carries a dismal prognosis. Inefficient drug delivery across the blood brain barrier (BBB), an immunosuppressive tumor microenvironment (TME) and ...
Kaushik Banerjee +22 more
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Gene Therapy for Acute Respiratory Distress Syndrome
Frontiers in Physiology, 2022 Acute respiratory distress syndrome (ARDS) is a devastating clinical syndrome that leads to acute respiratory failure and accounts for over 70,000 deaths per year in the United States alone, even prior to the COVID-19 pandemic.
Jing Liu +3 more
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Barriers and recent advances in non-viral vectors targeting the lungs for cystic fibrosis gene therapy [PDF]
Nanomedicine Journal, 2019 Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in CFTR genes that affect chloride ion channel. The CF is a good nominee for gene therapy as the asymptomatic carriers are phenotypically normal, and the desired cells are ...
Faisal Qaisar +3 more
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Applications and developments of gene therapy drug delivery systems for genetic diseases
Asian Journal of Pharmaceutical Sciences, 2021 Genetic diseases seriously threaten human health and have always been one of the refractory conditions facing humanity. Currently, gene therapy drugs such as siRNA, shRNA, antisense oligonucleotide, CRISPR/Cas9 system, plasmid DNA and miRNA have shown ...
Xiuhua Pan +6 more
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Gene Therapy for Regenerative Medicine
Pharmaceutics, 2023 The development of biological methods over the past decade has stimulated great interest in the possibility to regenerate human tissues. Advances in stem cell research, gene therapy, and tissue engineering have accelerated the technology in tissue and ...
Hossein Hosseinkhani +3 more
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Advances of non-viral nanometer vectors delivery systemfor siRNA
生物医学转化, 2021 The delivery of small interfering RNA is now mainly through viral vector delivery, chemicalmodification delivery, microinjection delivery, and non-viral nanometer vector delivery.
Geng Xiang, Huang Meizhou, Li Jianyong
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Antibiotics, 2020 Aminoglycosides are a class of naturally occurring and semi synthetic antibiotics that have been used for a long time in fighting bacterial infections.
Maria Cristina Bellucci +1 more
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Vectors for Glioblastoma Gene Therapy: Viral & Non-Viral Delivery Strategies
Nanomaterials, 2019 Glioblastoma multiforme is the most common and aggressive primary brain tumor. Even with aggressive treatment including surgical resection, radiation, and chemotherapy, patient outcomes remain poor, with five-year survival rates at only 10%.
Breanne Caffery +2 more
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Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors
Biomedicines, 2013 Viral vectors have been extensively studied due to their great transduction efficiency compared to non-viral vectors. These vectors have been used extensively in gene therapy, enabling the comprehension of, not only the advantages of these vectors, but ...
Cristian Capasso +2 more
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