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Viral and non-viral vectors in gene therapy: current state and clinical perspectives

EBioMedicine
Summary: Advancements in gene therapy have achieved significant milestones in treating human diseases, offering renewed hope to patients with limited options.
Guannan Geng, Yixin Xu, Ziying Hu, Hui Wang, Xiaoyun Chen, Wei Yuan, Yilai Shu   +6 more
doaj   +3 more sources

Application of Viral Vectors for Vaccine Development with a Special Emphasis on COVID-19

Viruses, 2020
Viral vectors can generate high levels of recombinant protein expression providing the basis for modern vaccine development. A large number of different viral vector expression systems have been utilized for targeting viral surface proteins and tumor ...
Kenneth Lundstrom
doaj   +3 more sources

Membrane Chromatography-Based Downstream Processing for Cell-Culture Produced Influenza Vaccines

Vaccines, 2022
New influenza strains are constantly emerging, causing seasonal epidemics and raising concerns to the risk of a new global pandemic. Since vaccination is an effective method to prevent the spread of the disease and reduce its severity, the development of
Zeyu Yang, Xingge Xu, Cristina A. T. Silva, Omar Farnos, Alina Venereo-Sanchez, Cécile Toussaint, Shantoshini Dash, Irene González-Domínguez, Alice Bernier, Olivier Henry, Amine Kamen   +10 more
doaj   +1 more source

Development of an Integrated Continuous Manufacturing Process for the rVSV-Vectored SARS-CoV-2 Candidate Vaccine

Vaccines, 2023
The administration of viral vectored vaccines remains one of the most effective ways to respond to the ongoing novel coronavirus disease 2019 (COVID-19) pandemic.
Zeyu Yang, Barbara Cristina Martins Fernandes Paes, Julia Puppin Chaves Fulber, Michelle Yen Tran, Omar Farnós, Amine A. Kamen   +5 more
doaj   +1 more source

Process Development for Newcastle Disease Virus-Vectored Vaccines in Serum-Free Vero Cell Suspension Cultures

Vaccines, 2021
The ongoing COVID-19 pandemic drew global attention to infectious diseases, attracting numerous resources for development of pandemic preparedness plans and vaccine platforms—technologies with robust manufacturing processes that can quickly be pivoted to
Julia Puppin Chaves Fulber, Omar Farnós, Sascha Kiesslich, Zeyu Yang, Shantoshini Dash, Leonardo Susta, Sarah K. Wootton, Amine A. Kamen   +7 more
doaj   +1 more source

Development of a scalable and robust AEX method for enriched rAAV preparations in genome-containing VCs of serotypes 5, 6, 8, and 9

Molecular Therapy: Methods & Clinical Development, 2021
Removal of empty capsids from adeno-associated virus (AAV) manufacturing lots remains a critical step in the downstream processing of AAV clinical-grade batches.
Pranav R.H. Joshi, Alice Bernier, Pablo D. Moço, Joseph Schrag, Parminder S. Chahal, Amine Kamen   +5 more
doaj   +1 more source

Development and Scalable Production of Newcastle Disease Virus-Vectored Vaccines for Human and Veterinary Use

Viruses, 2022
The COVID-19 pandemic has highlighted the need for efficient vaccine platforms that can rapidly be developed and manufactured on a large scale to immunize the population against emerging viruses.
Julia P. C. Fulber, Amine A. Kamen
doaj   +1 more source

Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation

Vaccines, 2020
Vaccine design strategies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are focused on the Spike protein or its subunits as the main antigen target of neutralizing antibodies. In this work, we propose rapid production methods of an
Omar Farnós, Alina Venereo-Sánchez, Xingge Xu, Cindy Chan, Shantoshini Dash, Hanan Chaabane, Janelle Sauvageau, Fouad Brahimi, Uri Saragovi, Denis Leclerc, Amine A. Kamen   +10 more
doaj   +1 more source

Intranasally Delivered Adenoviral Vector Protects Chickens against Newcastle Disease Virus: Vaccine Manufacturing and Stability Assessments for Liquid and Lyophilized Formulations

Vaccines, 2023
Newcastle disease (ND) remains a critical disease affecting poultry in sub-Saharan Africa. In some countries, repeated outbreaks have a major impact on local economies and food security.
Omar Farnós, Barbara Cristina Martins Fernandes Paes, Belayneh Getachew, Samia Rourou, Ameni Chaabene, Esayas Gelaye, Takele A. Tefera, Amine A. Kamen   +7 more
doaj   +1 more source

Recent Advances in Lipid Nanoparticles for Delivery of mRNA

Pharmaceutics, 2022
Messenger RNA (mRNA), which is composed of ribonucleotides that carry genetic information and direct protein synthesis, is transcribed from a strand of DNA as a template.
Lei Yang, Liming Gong, Ping Wang, Xinghui Zhao, Feng Zhao, Zhijie Zhang, Yunfei Li, Wei Huang   +7 more
doaj   +1 more source