Results 91 to 100 of about 205,833 (355)

Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism [PDF]

, 2013
The formation of a protective protein container is an essential step in the life-cycle of most viruses. In the case of single-stranded (ss)RNA viruses, this step occurs in parallel with genome packaging in a co-assembly process.
Bakker, S.E., Barker, A.M., Borodavka, A., Dykeman, Eric, Ford, R.J., Pearson, A.R., Phillips, S.E.V., Ranson, N.A., Stockley, P.G., Tuma, R., Twarock, R.   +10 more
core   +2 more sources

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

β-Coronaviruses exploit ESCRT for virion assembly and egress

mBio
β-Coronaviruses assemble at the endoplasmic reticulum-to-Golgi compartment and exit cells through the lysosomal trafficking pathway. However, the molecular mechanisms of virion assembly and egress are largely unknown. Here, we report that β-coronaviruses
Yuanyuan Zhang, Linlong Huang, Chaoqi Ren, Weiyang Wang, Xinlu Wang, Guangxia Gao   +5 more
doaj   +1 more source

IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity

Retrovirology, 2014
BackgroundInterferon induced transmembrane proteins 1, 2 and 3 (IFITMs) belong to a family of highly related antiviral factors that have been shown to interfere with a large spectrum of viruses including Filoviruses, Coronaviruses, Influenza virus ...
Kevin Tartour, Romain Appourchaux, J. Gaillard, X. Nguyen, S. Durand, Jocelyn Turpin, É. Beaumont, E. Roch, Grégory Berger, R. Mahieux, D. Brand, P. Roingeard, A. Cimarelli   +12 more
semanticscholar   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Carboxyl‐Terminal Region of the Maturation Protein of RNA Coliphage Qβ Mediates Host Attachment, Virion Formation, and Cell Lysis [PDF]

Genes Cells
The capsid of the single‐stranded RNA coliphage Qβ has a maturation (A2) protein that penetrates the capsid. The N‐terminal β‐region of A2 is exposed on the surface, and the C‐terminal α‐region is located inside the capsid and binds the genomic RNA. In this study, we showed that Qβ attached to the F‐pilus of the host via A2.
Kajitani M, Hakoshima N, Inokuchi Y.
europepmc   +2 more sources

Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]

, 2014
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis, Gonzalez, Silvia Adriana   +1 more
core   +4 more sources

Phosphoprotein Component of Vaccinia Virions [PDF]

Journal of Virology, 1973
The recent discovery of a protein kinase activity in vaccinia virions led us to search for a viral protein which is phosphorylated in vivo. Vaccinia virus was radioactively labeled by infecting cells in the presence of 32 P 1 .
H, Rosemond, B, Moss
openaire   +2 more sources

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

Herpesvirus glycoproteins undergo multiple antigenic changes before membrane fusion.

PLoS ONE, 2012
Herpesvirus entry is a complicated process involving multiple virion glycoproteins and culminating in membrane fusion. Glycoprotein conformation changes are likely to play key roles.
Daniel L Glauser, Anne-Sophie Kratz, Philip G Stevenson   +2 more
doaj   +1 more source