Results 31 to 40 of about 205,833 (355)

Protein Composition of the Bovine Herpesvirus 1.1 Virion

Veterinary Sciences, 2017
Bovine herpesvirus (BoHV) type 1 is an important agricultural pathogen that infects cattle and other ruminants worldwide. Acute infection of the oro-respiratory tract leads to immune suppression and allows commensal bacteria to infect an otherwise ...
Kaley A. Barber, Hillary C. Daugherty, Stephanie E. Ander, Victoria A. Jefferson, Leslie A. Shack, Tibor Pechan, Bindu Nanduri, Florencia Meyer   +7 more
doaj   +1 more source

Relationship between hemagglutinin stability and influenza virus persistence after exposure to low pH or supraphysiological heating.

PLoS Pathogens, 2021
The hemagglutinin (HA) surface glycoprotein is triggered by endosomal low pH to cause membrane fusion during influenza A virus (IAV) entry yet must remain sufficiently stable to avoid premature activation during virion transit between cells and hosts. HA
Guohua Yang, Chet R Ojha, Charles J Russell   +2 more
doaj   +1 more source

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

Kinetics of acute hepatitis B virus infection in humans [PDF]

, 2001
Using patient data from a unique single source outbreak of hepatitis B virus (HBV) infection, we have characterized the kinetics of acute HBV infection by monitoring viral turnover in the serum during the late incubation and clinical phases of the ...
Brown, D., Dusheiko, G.M., Emery, V.C., Murray, J.M., Perelson, A.S., Webster, G.J.M., Whalley, S.A.   +6 more
core   +1 more source

HIV-1 Infection of T Cells and Macrophages Are Differentially Modulated by Virion-Associated Hck: A Nef-Dependent Phenomenon

Viruses, 2013
The proline repeat motif (PxxP) of Nef is required for interaction with the SH3 domains of macrophage-specific Src kinase Hck. However, the implication of this interaction for viral replication and infectivity in macrophages and T lymphocytes remains ...
Gilda Tachedjian, Alison Greenway, Johnson Mak, Alyssa Cornall   +3 more
doaj   +1 more source

Dimerisation of HIV-2 genomic RNA is linked to efficient RNA packaging, normal particle maturation and viral infectivity. [PDF]

, 2007
BACKGROUND: Retroviruses selectively encapsidate two copies of their genomic RNA, the Gag protein binding a specific RNA motif in the 5' UTR of the genome.
Andrew ML Lever (60785), Anne L'Hernault (60782), Jane S Greatorex (60783), R Anthony Crowther (60784)   +3 more
core   +3 more sources

An alphaherpesvirus exploits antimicrobial beta-defensins to initiate respiratory tract infection [PDF]

, 2020
beta-Defensins protect the respiratory tract against the myriad of microbial pathogens entering the airways with each breath. However, this potentially hostile environment is known to serve as a portal of entry for herpesviruses.
Boyen, Filip, Daled, Simon, Dhaenens, Maarten, Laval, Kathlyn, Nauwynck, Hans, Pasmans, Frank, Poelaert, Katrien, Van Cleemput, Jolien, Vanderheijden, Nathalie   +8 more
core   +2 more sources

Yeast two hybrid analyses reveal novel binary interactions between human cytomegalovirus-encoded virion proteins. [PDF]

PLoS ONE, 2011
Human cytomegalovirus (HCMV) is the largest human herpesvirus and its virion contains many viral encoded proteins found in the capsid, tegument, and envelope.
Aaron To, Yong Bai, Ao Shen, Hao Gong, Sean Umamoto, Sangwei Lu, Fenyong Liu   +6 more
doaj   +1 more source

A nuanced role of the small loop of hepatitis B virus small envelope protein in virion morphogenesis and secretion

Journal of Biomedical Science, 2021
Background The virion secretion mechanism of human hepatitis B virus (HBV) remains to be investigated. In our current study, we characterized a reverse transcriptase mutant, which changed from the YMDD motif to YMHA.
Chih-Hsu Chang, Shu-Fan Chou, Chiaho Shih   +2 more
doaj   +1 more source

PVP-SVM: Sequence-Based Prediction of Phage Virion Proteins Using a Support Vector Machine

Frontiers in Microbiology, 2018
Accurately identifying bacteriophage virion proteins from uncharacterized sequences is important to understand interactions between the phage and its host bacteria in order to develop new antibacterial drugs.
Balachandran Manavalan, T. Shin, Gwang Lee   +2 more
semanticscholar   +1 more source