Results 71 to 80 of about 3,105,782 (329)

Determinants of Virological Failure Among Adult Clients on First-Line Antiretroviral Therapy in Amhara Regional State, Northeast Ethiopia. A Case –Control Study

HIV/AIDS: Research and Palliative Care, 2020
Zinabu Fentaw, Assresie Molla, Shambel Wedajo, Wondwosen Mebratu School of Public Health, Wollo University College of Medicine and Health Science, Dessie, Amhara Region, EthiopiaCorrespondence: Zinabu FentawSchool of Public Health, Wollo University ...
Fentaw Z, Molla A, Wedajo S, Mebratu W
doaj  

Determinants of virological failure and antiretroviral drug resistance in Mozambique [PDF]

Journal of Antimicrobial Chemotherapy, 2015
The objective of this study was to inform public health actions to limit first-line ART failure and HIV drug resistance in Mozambique.This was a cross-sectional study. HIV-1-infected adults on first-line ART for at least 1 year attending routine visits in the Manhiça District Hospital, in a semi-rural area in southern Mozambique with no HIV-1 RNA ...
Rupérez, María, Pou, Christian, Maculuve, Sonia, Cedeño, Samandhy, Luis, Leopoldina, Rodríguez, Judith, Letang, Emilio, Moltó, José, Macete, Eusébio, Clotet, Bonaventura, Alonso, Pedro, Menéndez, Clara, Naniche, Denise, Paredes, Roger   +13 more
openaire   +5 more sources

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Racial Disparities in HIV Virologic Failure: Do Missed Visits Matter? [PDF]

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2009
Racial/ethnic health care disparities are well described in people living with HIV/AIDS, although the processes underlying observed disparities are not well elucidated.A retrospective analysis nested in the University of Alabama at Birmingham 1917 Clinic Cohort observational HIV study evaluated patients between August 2004 and January 2007.
Michael J, Mugavero, Hui-Yi, Lin, Jeroan J, Allison, Thomas P, Giordano, James H, Willig, James L, Raper, Nelda P, Wray, Stephen R, Cole, Joseph E, Schumacher, Susan, Davies, Michael S, Saag   +10 more
openaire   +2 more sources

Viral Load Monitoring of Antiretroviral Therapy, cohort viral load and HIV transmission in Southern Africa: A Mathematical Modelling Analysis [PDF]

, 2012
In low-income settings, treatment failure is often identified using CD4 cell count monitoring. Consequently, patients remain on a failing regimen, resulting in a higher risk of transmission.
Attia, Bacaer, Barth, Bunnell, Bunnell, Charlebois, Cohen, Cohen, Das, Dodd, Egger, Fox, Granich, Hallett, Keiser, Keiser, Keiser, Kitahata, Lucas, Mastro, Mee, Mills, Petersen, Phillips, Pingen, Powers, Quinn, Schackman, Sterne, Wilson, Wright   +30 more
core   +2 more sources

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

Virological failure after 1 year of first-line ART is not associated with HIV minority drug resistance in rural Cameroon [PDF]

, 2017
Objectives The aim of this study was to describe clinical and virological outcomes in therapy-naive HIV-1-positive patients treated in a routine ART programme in rural Cameroon.
Awasom, C., Burchard, G. D., Campbell, N. K., Drexler, J. F., Feldt, T., Hammerl, R., Jochum, J., Metzner, K. J., Nassimi, N., Raymond, Y., Schmiedel, S., Taka, N., van Lunzen, J., Zoufaly, A.   +13 more
core  

Virological outcomes of second-line protease inhibitor-based treatment for human immunodeficiency virus type 1 in a high-prevalence rural South African setting: a competing-risks prospective cohort analysis [PDF]

, 2017
Background. Second-line antiretroviral therapy (ART) based on ritonavir-boosted protease inhibitors (bPIs) represents the only available option after first-line failure for the majority of individuals living with human immunodeficiency virus (HIV ...
2LADY Study Group, Alexandra Calmy, Anne Derache, ANRS 12249 TasP Study Group, Collins Iwuji, Dami Collier, DART Virology Group and Trial Team, Deenan Pillay, EARNEST Trial Team, Francois Dabis, National Department of Health, National Department of Health, Nonhlanhla Okesola, PharmAccess African Studies to Evaluate Resistance (PASER), PharmAccess African Studies to Evaluate Resistance (PASER), Ravindra K. Gupta, SECOND-LINE, SECOND-LINE Study Group, Southern African Treatment and Resistance Network, TenoRes Study Group, Tulio de Oliveira, World Health Organization, World Health Organization   +22 more
core   +3 more sources

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

Multicenter study in Turkiye of unsuppressed viremia in people living with human immunodeficiency virus: aegean experience

BMC Infectious Diseases
Introduction/Objective This Turkish study aimed to investigate the factors that contribute to the failure of virological suppression in people with human immunodeficiency virus (HIV) receiving antiretroviral therapy (ART).
Ilkay Akbulut, Zeynep Sedef Varol, Veysel Akca, Basak Gol Serin, Emel Erogul, Ilker Odemiş, Seniha Senbayrak, Sabri Atalay   +7 more
doaj   +1 more source