Results 141 to 150 of about 1,322 (161)
Rotaviruses Associate with Cellular Lipid Droplet Components To Replicate in Viroplasms, and Compounds Disrupting or Blocking Lipid Droplets Inhibit Viroplasm Formation and Viral Replication [PDF]
Journal of Virology, 2010 ABSTRACT Rotaviruses are a major cause of acute gastroenteritis in children worldwide. Early stages of rotavirus assembly in infected cells occur in viroplasms. Confocal microscopy demonstrated that viroplasms associate with lipids and proteins (perilipin A, ADRP) characteristic of lipid droplets (LDs).
Michael Gill +2 more
exaly +3 more sources
Lipid droplets form complexes with viroplasms and are crucial for rotavirus replication [PDF]
Current Opinion in Virology, 2016 Recent evidence has demonstrated that a variety of pathogens target cellular lipid metabolism for their replication. Lipid droplets are a major contributor to lipid homeostasis and contain neutral fats but are also recognized as dynamic organelles involved in signal transduction, membrane trafficking and modulation of immune and inflammatory responses.
Sue E Crawford, Ulrich Desselberger
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Virology, 2022
Rotavirus (RV) replication occurs in cytoplasmic membrane-less, electron-dense inclusions termed viroplasms, composed of viral and cellular elements. These inclusions have been shown to colocalize with components of the lipid droplets (LDs), unique organelles that play an essential role in lipid metabolism.
Catherine Eichwald +2 more
exaly +4 more sources
Rotavirus (RV) replication occurs in cytoplasmic membrane-less, electron-dense inclusions termed viroplasms, composed of viral and cellular elements. These inclusions have been shown to colocalize with components of the lipid droplets (LDs), unique organelles that play an essential role in lipid metabolism.
Catherine Eichwald +2 more
exaly +4 more sources
Identification of a Small Molecule That Compromises the Structural Integrity of Viroplasms and Rotavirus Double-Layered Particles [PDF]
Journal of Virology, 2018 Despite the availability of two attenuated vaccines, rotavirus (RV) gastroenteritis remains an important cause of mortality among children in developing countries, causing about 215,000 infant deaths annually.
Catherine Eichwald +2 more
exaly +4 more sources
2022
Rotavirus cell infection and immunofluorescence. MA-104 Clone 1 cells (American Type Culture Collection; ATCC:CRL-2378.1; RRID:CVCL_3846) were cultured in DMEM-RS media supplemented with 5% fetal bovine serum at 37°C and 5% CO2. Prior to infection, Rhesus rotavirus (RRV) was activated with trypsin (10 μg/ml) for 30 min at 37°C.
openaire +1 more source
Rotavirus cell infection and immunofluorescence. MA-104 Clone 1 cells (American Type Culture Collection; ATCC:CRL-2378.1; RRID:CVCL_3846) were cultured in DMEM-RS media supplemented with 5% fetal bovine serum at 37°C and 5% CO2. Prior to infection, Rhesus rotavirus (RRV) was activated with trypsin (10 μg/ml) for 30 min at 37°C.
openaire +1 more source
Rotavirus Genome Replication and Morphogenesis: Role of the Viroplasm
2006The rotaviruses, members of the family Reoviridae, are icosahedral triple-layered viruses with genomes consisting of 11 segments of double-stranded (ds)RNA. A characteristic feature of rotavirus-infected cells is the formation of large cytoplasmic inclusion bodies, termed viroplasms.
Patton, J. +4 more
openaire +3 more sources
Micron, 2017
Viroplasms of members of the family Reoviridae are considered to be viral factories for genome replication and virion assembly. Globular and filamentous phenotypes have different components and probably have different functions. We used transmission electron microscopy and electron tomography to examine the structure and components of the two viroplasm
Jian Yang, Heng-Mu Zhang
exaly +3 more sources
Viroplasms of members of the family Reoviridae are considered to be viral factories for genome replication and virion assembly. Globular and filamentous phenotypes have different components and probably have different functions. We used transmission electron microscopy and electron tomography to examine the structure and components of the two viroplasm
Jian Yang, Heng-Mu Zhang
exaly +3 more sources
Role of the Sonchus Yellow Net Virus N Protein in Formation of Nuclear Viroplasms [PDF]
Journal of Virology, 2007 ABSTRACT Sonchus yellow net virus is a plant nucleorhabdovirus whose nucleocapsid (N), phosphoprotein (P), and polymerase (L) proteins form large viroplasms in the nuclei of infected plants (C. R. F. Martins, J. A. Johnson, D. M. Lawrence, T. J. Choi, A. Pisi, S. L. Tobin, D. Lapidus, J. D. O. Wagner, S.
Andrew O Jackson
exaly +3 more sources
In Vitro Synthesis of Cauliflower Mosaic Virus DNA in Viroplasms
1984Cauliflower Mosaic Virus (CaMV) is a DNA plant virus, and as such an attractive model for studying the molecular biology of plants (1, 2). Its genome is a circular double-stranded molecule, 8 kb in length. The encapsidated form possesses three single-stranded discontinuities (3) where the 5’ and 3’ ends of the interrupted strand overlap one another (4,
J M, Bonneville +4 more
openaire +2 more sources
Cauliflower mosaic virus-induced viroplasms support viral DNA synthesis in a cell-free system
Virology, 1984Viroplasms are the main cytological modifications observed upon infection of Brassica cells by cauliflower mosaic virus (CaMV). Previous experiments suggested that the replication of viral DNA proceeded in two steps, starting in the nucleus and going on to the viroplasms.
N, Modjtahedi +5 more
exaly +3 more sources