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Lipid composition modulates interactions of p7 viroporin during membrane insertion
Journal of Structural Biology, 2023Viral proteins interact with lipid membranes during various stages in the viral life cycle to propagate infection. p7 is an ion channel forming protein of Hepatitis C virus (HCV) that participates in viral assembly. Studies show that it has close ties to lipid metabolism in the cell and anionic phosphatidylserine (PS) lipids are suggested to be key for
Oluwatoyin Campbell +1 more
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Functional and Structural Characterization of 2B Viroporin Membranolytic Domains
Biochemistry, 2008Nonstructural 2B viroporin is an intracellularly produced pore-forming protein required for effective enteroviral and rhinoviral replication. The sequence of 2B displays two putative interconnected transmembrane domains, which are predicted to insert into the negatively charged membranes of target organelles forming an integral hairpin.
Silvia, Sánchez-Martínez +5 more
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Oligomeric states of an Influenza-encoded PB1-F2 viroporin
2023ABSTRACTInfluenza Viruses have always been a major health concern due to their highly contagious nature. The PB1-F2 viroporin encoded by the influenza A virus is known to be a pro-apoptotic protein involved in cell death induction of the host immune cells.
Sehrish Jamal +2 more
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SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway
Virology, 2022Huanzhou Xu +2 more
exaly
Romo1 is a mitochondrial nonselective cation channel with viroporin-like characteristics
Journal of Cell Biology, 2018Gi Young Lee, Hye-Ra Lee, C Justin Lee
exaly
Viroporin activity and membrane topology of classic swine fever virus p7 protein
International Journal of Biochemistry and Cell Biology, 2013Shiqi Sun
exaly

