Results 181 to 190 of about 4,200 (198)

NS2A comprises a putative viroporin of Dengue virus 2 [PDF]

Virulence, 2017
During infection with Dengue virus (DENV), host cells undergo a series of detrimental functional changes, including profound remodelling and redistribution of cell membrane structures,1,4 which giv...
Nicolas Villegas-Sepúlveda, Moises Leon Juarez, Goldie Oza   +2 more
exaly   +3 more sources

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Mechanistic Insights into the Divergent Membrane Activities of a Viroporin from Chikungunya Virus and Its Transframe Variant.

ACS Infectious Diseases
Alphaviruses, a genus of vector-borne viruses in the Togaviridae family, encode a small ion-channel-forming protein, 6K, and its transframe variant (TF) during infections.
Kirti Suhag, Subhomoi Borkotoky, Shumaila Iqbal Siddiqui, J. Kumar, Chandra Shekhar Kumar, Pushkar Tatiya, Subhendu Ghosh, Manidipa Banerjee   +7 more
semanticscholar   +1 more source

Advanced Computational Approaches to Evaluate the Potential of New-Generation Adamantane-Based Drugs as Viroporin Inhibitors: A Case Study on SARS-CoV-2.

Journal of Physical Chemistry B
Traditional adamantane derivatives have demonstrated potential in inhibiting ion channels and viroporins of influenza A virus. Viroporins are oligomeric viral proteins that form membrane channels, facilitating cation transport across host cell membranes,
Sarina Yousefbeigi, Farah Marsusi
semanticscholar   +1 more source

The plant rhabdovirus viroporin P9 facilitates insect-mediated virus transmission in barley.

The Plant Cell
Potassium (K+) plays crucial roles in both plant development and immunity. However, the function of K+ in plant-virus interactions remains largely unknown.
Qiang Gao, Ying Zang, J. Qiao, Zong-Ying Zhang, Ying Wang, Chenggui Han, Xian-Bing Wang   +6 more
semanticscholar   +1 more source

Beyond the Viroporin: The Envelope Protein as a Therapeutic Target in Viral Immunomodulation

Reviews in Medical Virology
In their comprehensive review, Shekhar et al. (Rev Med Virol. 2025; 35:e70067) provide a valuable synthesis of the viral envelope (E) protein's role in subverting innate immunity and its potential as a pharmacological target. While we commend this timely
Du-Jiang Yang, Guo-You Wang
semanticscholar   +1 more source

Lipid Composition Modulates Interactions of p7 Viroporin during Membrane Insertion.

Journal of Structural Biology, 2023
Viral proteins interact with lipid membranes during various stages in the viral life cycle to propagate infection. p7 is an ion channel forming protein of Hepatitis C virus (HCV) that participates in viral assembly. Studies show that it has close ties to
Oluwatoyin Campbell, Viviana Monje-Galvan   +1 more
semanticscholar   +1 more source

[The antiviral targeting potential of viroporins].

Ugeskrift for laeger, 2022
Viroporins are ion channels found in many viruses, where they contribute to virus life cycle and thereby pathogenesis. Viroporin targeting is a known, yet largely unexplored, therapeutic strategy so far only used in Influenza A with the drugs amantadine and rimantadine.
John D, Sund, Signe, Bollerup, Jekob B, Glamann, Caroline An, Vinten, Louise R, Jensen, Trine L, Toft-Bethelsen, Bo H, Bentzen, Thomas N, Kledal, Nina, Weis, Mette, Rosenkilde   +9 more
openaire   +1 more source

Compounds based on Adamantyl-Substituted Amino Acids and Peptides as Potential Antiviral Drugs Acting as Viroporin Inhibitors.

Current pharmaceutical design
The discussion has revolved around the derivatives of amino acids and peptides containing carbocycles and their potential antiviral activity in vitro against influenza A, hepatitis C viruses, and coronavirus.
T. M. Garaev, T. Grebennikova, V. V. Lebedeva, V. Avdeeva, V. F. Larichev   +4 more
semanticscholar   +1 more source

Functional and Structural Characterization of 2B Viroporin Membranolytic Domains

Biochemistry, 2008
Nonstructural 2B viroporin is an intracellularly produced pore-forming protein required for effective enteroviral and rhinoviral replication. The sequence of 2B displays two putative interconnected transmembrane domains, which are predicted to insert into the negatively charged membranes of target organelles forming an integral hairpin.
Silvia, Sánchez-Martínez, Nerea, Huarte, Rubén, Maeso, Vanessa, Madan, Luis, Carrasco, José L, Nieva   +5 more
openaire   +2 more sources

Membrane-Active Peptides Derived from Picornavirus 2B Viroporin

Current Protein & Peptide Science, 2012
Viruses have evolved membrane-restructuring mechanisms for sustaining entry into cells, genome replication and release from host cells. Picornavirus 2B, a non-structural protein required for effective viral replication, functions as a potent intracellular pore-forming toxin by altering the permeability of cellular endomembranes.
Sánchez-Martínez, Silvia, Madan, Vanesa, Carrasco Llamas, Luis, Nieva, José Luis   +3 more
openaire   +3 more sources