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Lipid composition modulates interactions of p7 viroporin during membrane insertion

Journal of Structural Biology, 2023
Viral proteins interact with lipid membranes during various stages in the viral life cycle to propagate infection. p7 is an ion channel forming protein of Hepatitis C virus (HCV) that participates in viral assembly. Studies show that it has close ties to lipid metabolism in the cell and anionic phosphatidylserine (PS) lipids are suggested to be key for
Oluwatoyin Campbell   +1 more
openaire   +2 more sources

Functional and Structural Characterization of 2B Viroporin Membranolytic Domains

Biochemistry, 2008
Nonstructural 2B viroporin is an intracellularly produced pore-forming protein required for effective enteroviral and rhinoviral replication. The sequence of 2B displays two putative interconnected transmembrane domains, which are predicted to insert into the negatively charged membranes of target organelles forming an integral hairpin.
Silvia, Sánchez-Martínez   +5 more
openaire   +2 more sources

Oligomeric states of an Influenza-encoded PB1-F2 viroporin

2023
ABSTRACTInfluenza Viruses have always been a major health concern due to their highly contagious nature. The PB1-F2 viroporin encoded by the influenza A virus is known to be a pro-apoptotic protein involved in cell death induction of the host immune cells.
Sehrish Jamal   +2 more
openaire   +1 more source

SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway

Virology, 2022
Huanzhou Xu   +2 more
exaly  

Single-molecule conformational dynamics of viroporin ion channels regulated by lipid-protein interactions

Bioelectrochemistry, 2021
Eneko Largo   +2 more
exaly  

A funnel-like viroporin

Nature Structural & Molecular Biology, 2013
openaire   +1 more source

Featured System Viroporins

Protein Structure Initiative Structural Genomics Knowledgebase, 2014
openaire   +1 more source

Romo1 is a mitochondrial nonselective cation channel with viroporin-like characteristics

Journal of Cell Biology, 2018
Gi Young Lee, Hye-Ra Lee, C Justin Lee
exaly  

Viroporin activity and membrane topology of classic swine fever virus p7 protein

International Journal of Biochemistry and Cell Biology, 2013
Shiqi Sun
exaly  

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