Results 181 to 190 of about 11,703 (213)
Some of the next articles are maybe not open access.
Nature Communications
Oncolytic viruses (OVs) hold promise for cancer treatment. However, the antitumor efficacy is limited. Microbiota plays a pivotal role in cancer treatment and its impact on oncolytic virotherapy is unknown.
Jiayu Zhang +20 more
semanticscholar +1 more source
Oncolytic viruses (OVs) hold promise for cancer treatment. However, the antitumor efficacy is limited. Microbiota plays a pivotal role in cancer treatment and its impact on oncolytic virotherapy is unknown.
Jiayu Zhang +20 more
semanticscholar +1 more source
Targeting gene-virotherapy of cancer [PDF]
Cell Research, 2006 Our purpose is to completely elimination of xenograft tumor in animal tumor model in order to work out a protocal for the cure of patient. Gene therapy and viral therapy for cancer have got some therapeutic effects, but both have no great breakthrough.
Xin Yuan Liu, Jin Fa Gu
exaly +3 more sources
Oncolytic virotherapy and tumor microenvironment modulation
Clinical and Experimental Medicine (Testo stampato)Oncolytic viruses (OVs) have emerged as a transformative approach in cancer therapy, offering tumor-specific lysis while sparing normal tissues. In addition to their direct cytolytic effects, OVs actively reshape the tumor microenvironment (TME) by ...
Sebastián Rivera-Orellana +11 more
semanticscholar +1 more source
2018
Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type and non-engineered in vitro-passaged virus strains and vaccine strains (first generation oncolytic viruses ...
Daisuke, Watanabe, Fumi, Goshima
openaire +2 more sources
Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type and non-engineered in vitro-passaged virus strains and vaccine strains (first generation oncolytic viruses ...
Daisuke, Watanabe, Fumi, Goshima
openaire +2 more sources
Virotherapy of Neuroendocrine Tumors
Neuroendocrinology, 2012Most patients with small intestinal neuroendocrine tumors (SI-NETs), also referred to as midgut carcinoids, present with systemic disease at the time of diagnosis with metastases primarily found in regional lymph nodes and the liver. Curative treatment is not available for these patients and there is a need for novel and specific therapies.
openaire +2 more sources
Introduction to Oncolytic Virotherapy
2019Oncolytic viruses exploit key hallmarks of cancer for replication in malignant cells, leading to tumor cell lysis, modulation of the tumor microenvironment and in situ vaccination effects. Diverse virus platforms have been developed as oncolytic vectors and designed for improved tumor specificity, intratumoral spread, therapeutic gene delivery and ...
Christine E, Engeland, John C, Bell
openaire +2 more sources
International Journal of Molecular Sciences
Head and neck cancer (HNC) represents a challenging oncological entity with significant morbidity and mortality rates. Despite advances in conventional therapies, including surgery, chemotherapy, and radiation therapy, the overall survival rates for ...
Francesca Spirito +10 more
semanticscholar +1 more source
Head and neck cancer (HNC) represents a challenging oncological entity with significant morbidity and mortality rates. Despite advances in conventional therapies, including surgery, chemotherapy, and radiation therapy, the overall survival rates for ...
Francesca Spirito +10 more
semanticscholar +1 more source
Oncolytic virotherapy reaches adolescence
Pediatric Blood & Cancer, 2010AbstractLytic viruses kill cells as a consequence of their normal replication life cycle. The idea of harnessing viruses to kill cancer cells arose over a century ago, before viruses were even discovered, from medical case reports of infections associated with cancer remissions.
Adrienne M, Hammill +2 more
openaire +2 more sources
Oncolytic virotherapy for multiple myeloma
Expert Opinion on Biological Therapy, 2008Current therapies for multiple myeloma (MM) are not curative, thus novel targeted therapeutics are being developed. One such targeted therapy is oncolytic virotherapy, wherein viruses specifically infect and kill the malignant plasma cells, leaving normal cells intact.This review provides an overview of the mechanisms and results of the oncolytic ...
Amaalia E, Stief, J Andrea, McCart
openaire +2 more sources
Tuning Cellular Metabolism for Cancer Virotherapy.
Cancer LettersOncolytic viruses (OVs) represent an emerging immunotherapeutic strategy owing to their capacity for direct tumor lysis and induction of antitumor immunity.
Dian Xiong +3 more
semanticscholar +1 more source