Results 21 to 30 of about 13,136,107 (398)
Whole genome SNP analysis suggests unique virulence factor differences of the Beijing and Manila families of Mycobacterium tuberculosis found in Hawaii. [PDF]
PLoS ONE, 2018 While tuberculosis (TB) remains a global disease, the WHO estimates that 62% of the incident TB cases in 2016 occurred in the WHO South-East Asia and Western Pacific regions.
Kent Koster +8 more
doaj +1 more source
Fundamental Research, 2022 Bacteria equipped with virulence systems based on highly bioactive small molecules can circumvent their host's defense mechanisms. Pathogens employing this strategy are currently threatening global rice production. In the present study, variations in the
Haruna Matsumoto +14 more
doaj +1 more source
A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway. [PDF]
, 2011 The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown ...
Bäumler, Andreas J +7 more
core +2 more sources
Exploring the Evolution of Virulence Factors through Bioinformatic Data Mining
mSystems, 2019 The molecular evolution of virulence factors is a central theme in our understanding of bacterial pathogenesis and host-microbe interactions. Using bioinformatics and genome data mining, recent studies have shed light on the evolution of important ...
Andrew C. Doxey +2 more
doaj +1 more source
Nature Communications, 2021 TcpC is a well characterised multifunctional virulence factor expressed by uropathogenic Eschericia coli. Here the authors show that TcpC also targets neutrophil NETosis via its E3 ligase functionality promoting the degradation of PAD4, and represents an
Qian Ou +12 more
doaj +1 more source
SARS-CoV-2 ORF8 accessory protein is a virulence factor
mBio, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes six accessory proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in pathogenesis.
M. Bello-Perez +12 more
doaj +1 more source
Identification of an essential virulence gene of cyprinid herpesvirus 3 [PDF]
, 2017 The genus Cyprinivirus consists of a growing list of phylogenetically related viruses, some of which cause severe economic losses to the aquaculture industry. The archetypal member, cyprinid herpesvirus 3 (CyHV-3) causes mass mortalities worldwide in koi
Boutier, Maxime +5 more
core +2 more sources
Nature Communications, 2017 Virulence-linked pathways in opportunistic pathogens are putative therapeutic targets that may be associated with less potential for resistance than targets in growth-essential pathways.
J. Bartell +6 more
semanticscholar +1 more source
PLoS ONE, 2020 Identification of bacterial virulence factors is critical for understanding disease pathogenesis, drug discovery and vaccine development. In this study we used two approaches to predict virulence factors of Burkholderia pseudomallei, the Gram-negative ...
Ben Vezina +3 more
doaj +1 more source
ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosis
Biomolecules, 2023 Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of the most successfully adapted human pathogens. Human-to-human transmission occurs at high rates through aerosols containing bacteria, but the pathogen evolved ...
Elsa Anes +3 more
doaj +1 more source