Results 11 to 20 of about 202,176 (263)
Frontiers in Microbiology, 2016 Bacterial traits that contribute to disease are termed ‘virulence factors’ and there is much interest in therapeutic approaches that disrupt such traits.
Elisa Granato +4 more
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Whole genome SNP analysis suggests unique virulence factor differences of the Beijing and Manila families of Mycobacterium tuberculosis found in Hawaii. [PDF]
PLoS ONE, 2018 While tuberculosis (TB) remains a global disease, the WHO estimates that 62% of the incident TB cases in 2016 occurred in the WHO South-East Asia and Western Pacific regions.
Kent Koster +8 more
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Fundamental Research, 2022 Bacteria equipped with virulence systems based on highly bioactive small molecules can circumvent their host's defense mechanisms. Pathogens employing this strategy are currently threatening global rice production. In the present study, variations in the
Haruna Matsumoto +14 more
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Exploring the Evolution of Virulence Factors through Bioinformatic Data Mining
mSystems, 2019 The molecular evolution of virulence factors is a central theme in our understanding of bacterial pathogenesis and host-microbe interactions. Using bioinformatics and genome data mining, recent studies have shed light on the evolution of important ...
Andrew C. Doxey +2 more
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Nature Communications, 2021 TcpC is a well characterised multifunctional virulence factor expressed by uropathogenic Eschericia coli. Here the authors show that TcpC also targets neutrophil NETosis via its E3 ligase functionality promoting the degradation of PAD4, and represents an
Qian Ou +12 more
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SARS-CoV-2 ORF8 accessory protein is a virulence factor
mBio, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes six accessory proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in pathogenesis.
M. Bello-Perez +12 more
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PLoS ONE, 2020 Identification of bacterial virulence factors is critical for understanding disease pathogenesis, drug discovery and vaccine development. In this study we used two approaches to predict virulence factors of Burkholderia pseudomallei, the Gram-negative ...
Ben Vezina +3 more
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ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosis
Biomolecules, 2023 Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of the most successfully adapted human pathogens. Human-to-human transmission occurs at high rates through aerosols containing bacteria, but the pathogen evolved ...
Elsa Anes +3 more
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Phosphorylation of CFP10 modulates Mycobacterium tuberculosis virulence
mBio, 2023 Virulence effectors secreted by Mycobacterium tuberculosis (Mtb) help subvert host immune mechanisms and, therefore, are critical for establishing infection and pathogenesis. However, knowledge in terms of signaling mechanisms that modulate the secretion
Basanti Malakar +9 more
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mBio, 2013 Vibrio cholerae is an aquatic organism that causes the severe acute diarrheal disease cholera. The ability of V. cholerae to cause disease is dependent upon the production of two critical virulence determinants, cholera toxin (CT) and the toxin ...
X. Renee Bina +4 more
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