Results 11 to 20 of about 4,443,372 (306)

Breaking the bad: Bacillus blocks fungal virulence factors

Microbial Cell, 2017
Fungal pathogens rely on the production of specific virulence factors during infection. Inhibiting such factors generally results in reduced fungal pathogenicity.
François L. Mayer, James W. Kronstad
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The central metabolism regulator EIIAGlc switches Salmonella from growth arrest to acute virulence through activation of virulence factor secretion [PDF]

, 2014
The ability of Salmonella to cause disease depends on metabolic activities and virulence factors. Here, we show that a key metabolic protein, EIIAGlc, is absolutely essential for acute infection, but not for Salmonella survival, in a mouse typhoid fever ...
Timo Glatter, Dirk Bumann,, Glatter, Timo, Glatter, T. ; https://orcid.org/, Mazé, Alain, Bumann, Dirk, Timo Glatter,, Dirk Bumann, Alain Mazé, Maze, A., Alain Mazé,, Bumann, D.   +11 more
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Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence [PDF]

, 2014
Bis-(3',5') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through
Caly, Delphine L., Joseph Ward (645977), Yvonne McCarthy (109070), Melanie Febrer (185470), Murdoch, Sarah L., Dow, J. Maxwell, Joseph Ward, Robert P. Ryan (108478), Ryan, Robert P., An, Shi Qi, An Shi-qi, Ryan Robert P., Shi-qi An, Robert P Ryan, J. Maxwell Dow (269095), J Maxwell Dow, McCarthy Yvonne, Caly Delphine L., Dow J. Maxwell, An, Shi-qi, Ward Joseph, Delphine L Caly, Yvonne McCarthy, McCarthy, Yvonne, Sarah L Murdoch, Melanie Febrer, Sarah L. Murdoch (645976), Ward, Joseph, Shi-qi An (5661025), Febrer Melanie, Febrer, Melanie, Delphine L. Caly (146386), Murdoch Sarah L.   +32 more
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Do Bacterial “Virulence Factors” Always Increase Virulence? A Meta-analysis of Pyoverdine Production inPseudomonas aeruginosa as a Test Case

Frontiers in Microbiology, 2016
Bacterial traits that contribute to disease are termed ‘virulence factors’ and there is much interest in therapeutic approaches that disrupt such traits.
Elisa Granato, Freya Harrison, Rolf Kümmerli, Adin Ross-Gillespie, Adin Ross-Gillespie   +4 more
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Whole genome SNP analysis suggests unique virulence factor differences of the Beijing and Manila families of Mycobacterium tuberculosis found in Hawaii. [PDF]

PLoS ONE, 2018
While tuberculosis (TB) remains a global disease, the WHO estimates that 62% of the incident TB cases in 2016 occurred in the WHO South-East Asia and Western Pacific regions.
Kent Koster, Angela Largen, Jeffrey T Foster, Kevin P Drees, Lishi Qian, Edward P Desmond, Xuehua Wan, Shaobin Hou, James T Douglas   +8 more
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SARS-CoV-2 ORF8 accessory protein is a virulence factor

mBio, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes six accessory proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in pathogenesis.
M. Bello-Perez, J. Hurtado-Tamayo, A. Z. Mykytyn, M. M. Lamers, R. Requena-Platek, D. Schipper, D. Muñoz-Santos, J. Ripoll-Gómez, A. Esteban, P. J. Sánchez-Cordón, L. Enjuanes, B. L. Haagmans, I. Sola   +12 more
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Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis [PDF]

, 2011
Streptococcus suis is one of the most important pathogens in pigs and is also an emerging zoonotic agent. After crossing the epithelial barrier, S. suis causes bacteraemia, resulting in meningitis, endocarditis and bronchopneumonia.
Smith, H.E., Smith, H E, H. E. Smith, R. Goethe, Rohde, Manfred, Valentin-Weigand, P., M. Rohde, Goethe, R, J. Willenborg, Willenborg, J, de Greeff, A, Goethe, R., Willenborg, J., A. de Greeff, Valentin-Weigand, P, De Greeff, A., Greeff, A., De, P. Valentin-Weigand, Fulde, M., M. Fulde, Fulde, M, Rohde, M.   +21 more
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Exploring the Evolution of Virulence Factors through Bioinformatic Data Mining

mSystems, 2019
The molecular evolution of virulence factors is a central theme in our understanding of bacterial pathogenesis and host-microbe interactions. Using bioinformatics and genome data mining, recent studies have shed light on the evolution of important ...
Andrew C. Doxey, Michael J. Mansfield, Briallen Lobb   +2 more
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Reprogramming of phytopathogen transcriptome by a non-bactericidal pesticide residue alleviates its virulence in rice

Fundamental Research, 2022
Bacteria equipped with virulence systems based on highly bioactive small molecules can circumvent their host's defense mechanisms. Pathogens employing this strategy are currently threatening global rice production. In the present study, variations in the
Haruna Matsumoto, Yuan Qian, Xiaoyan Fan, Sunlu Chen, Yanxia Nie, Kun Qiao, Dandan Xiang, Xinzhong Zhang, Meng Li, Bo Guo, Peilin Shen, Qiangwei Wang, Yunlong Yu, Tomislav Cernava, Mengcen Wang   +14 more
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Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections [PDF]

, 2006
The pro-inflammatory cytokine tumour necrosis factor alpha (TNF-alpha) is associated with malaria virulence (disease severity) in both rodents and humans.
Long, G H, Read, A F, Read, A. F., Chan, Brian, Long, G. H., Graham, Andrea, A. F. READ, G. H. LONG, Allen, J. E., Chan, B H K, A. L. GRAHAM, J. E. ALLEN, Allen, Judith, Graham, A. L., Allen, J E, Graham, A L, B. H. K. CHAN, Read, Andrew F, Chan, B. H K; id_orcid, Long, Gráinne Helen   +19 more
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