PLoS ONE, 2020 Identification of bacterial virulence factors is critical for understanding disease pathogenesis, drug discovery and vaccine development. In this study we used two approaches to predict virulence factors of Burkholderia pseudomallei, the Gram-negative ...
Ben Vezina +3 more
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Nature Communications, 2021 TcpC is a well characterised multifunctional virulence factor expressed by uropathogenic Eschericia coli. Here the authors show that TcpC also targets neutrophil NETosis via its E3 ligase functionality promoting the degradation of PAD4, and represents an
Qian Ou +12 more
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Evolutionary trade-offs underlie the multi-faceted virulence of Staphylococcus aureus [PDF]
, 2015 Date of Acceptance: 20/07/2015Bacterial virulence is a multifaceted trait where the interactions between pathogen and host factors affect the severity and outcome of the infection. Toxin secretion is central to the biology of many bacterial pathogens and
Williams, Barnabas +96 more
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ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosis
Biomolecules, 2023 Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of the most successfully adapted human pathogens. Human-to-human transmission occurs at high rates through aerosols containing bacteria, but the pathogen evolved ...
Elsa Anes +3 more
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Selection of virulence-associated determinants of Streptococcus suis serotype 2 by in vivo complementation [PDF]
, 2001 Within Streptococcus suis serotype 2, pathogenic, weakly pathogenic, and nonpathogenic strains can be found. We introduced a genomic library of a pathogenic strain into a weakly pathogenic strain.
Smith, H.E. +9 more
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Study of Virulence Factor Production in Candida Species Colonizer Isolated from Diabetic Patients [PDF]
, 2022 Candida is a yeast like fungus. It causes candidiasis which is a spectrum of disease from cutaneous, mucosal, systemic & multisystem dissemination. It is a coloniser of mucocutaneous surfaces of body but it is an opportunistic fungus causing severe type ...
Archana Wankhade +2 more
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Phosphorylation of CFP10 modulates Mycobacterium tuberculosis virulence
mBio, 2023 Virulence effectors secreted by Mycobacterium tuberculosis (Mtb) help subvert host immune mechanisms and, therefore, are critical for establishing infection and pathogenesis. However, knowledge in terms of signaling mechanisms that modulate the secretion
Basanti Malakar +9 more
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Predicting the virulence of MRSA from its genome sequence [PDF]
, 2014 This work is supported by the EC-FP7 program no. 245500 and the BBSRCMicrobial virulence is a complex and often multifactorial phenotype, intricately linked to a pathogen's evolutionary trajectory.
Josefsson, Elisabet, +89 more
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mBio, 2013 Vibrio cholerae is an aquatic organism that causes the severe acute diarrheal disease cholera. The ability of V. cholerae to cause disease is dependent upon the production of two critical virulence determinants, cholera toxin (CT) and the toxin ...
X. Renee Bina +4 more
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Relatedness of Streptococcus suis isolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits [PDF]
, 2001 We evaluated the genetic diversity of Streptococcus suis isolates of different serotypes by macrorestriction analysis and elucidated possible relationships between the genetic background, expression of potential virulence traits, and source of isolation.
Smith, H.E. +9 more
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