Results 161 to 170 of about 104,714 (231)

Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregative <i>Escherichia coli</i> O104:H4 outbreak strain. [PDF]

Microbiology (Reading)
Whelan R, Cyganek M, Oxley CL, Dickins B, Thomas JC, McVicker G.   +5 more
europepmc   +1 more source

Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla _CTX-M-15 and one rmpA2-associated virulence plasmid. [PDF]

Front Cell Infect Microbiol, 2022
Tian C, Xing M, Zhao Y, Fan X, Bai Y, Fu L, Wang S.   +6 more
europepmc   +1 more source

Emergence of Ceftazidime‐Avibactam‐Induced KPC Variants (KPC‐25/127) in Intracranial Infection and Implications for Clinical Management

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Novel KPC‐25 and first‐reported KPC‐127 sequentially evolved in one patient under CAZ‐AVI pressure, distinct mutations remodel enzyme activity to drive differential multidrug resistance. ABSTRACT The emergence of novel Klebsiella pneumoniae carbapenemase (KPC) variants contributing to clinical treatment failure poses a substantial threat to public ...
Ke Lei, Ying Tian, Chaoliang Xiong, Jing Lei, Dong Chen, Xiangni Bai, Mohd H. Abdul‐Aziz, Jiao Xie, Zeshi Liu   +8 more
wiley   +1 more source

Carbapenem-Resistant, Virulence Plasmid-Harboring Klebsiella pneumoniae, United States. [PDF]

Emerg Infect Dis
Jiang J, Long T, Porter AR, Lovey A, Lee A, Jacob JT, Arias CA, Bonomo R, Kalayjian R, Zhao Y, DeLeo FR, van Duin D, Kreiswirth BN, Chen L.   +13 more
europepmc   +1 more source

GcrR in Streptococcus mutans Inhibits the Morphological Transition of Candida albicans Through Ras1–cAMP/PKA Pathway in the Cross‐Kingdom Biofilms

Molecular Oral Microbiology, Volume 41, Issue 4, Page 188-200, August 2026.
ABSTRACT The dual‐species biofilms formed by Streptococcus mutans and Candida albicans exhibit enhanced cariogenic potential due to the production of extracellular polysaccharides (EPSs). The response regulator GcrR in S. mutans negatively regulates EPS synthesis, but its impact on dual‐species biofilms remains unclear.
Bin Zhang, Shihao Hou, Anqi Zhang, Jielin Yang, Wenjiao Zhang, Shijie Zhu, Hong Chen, Ruizhe Huang   +7 more
wiley   +1 more source

Development of Quorum Sensing Modulators of Streptococcus constellatus

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Using a rational design approach, novel Streptococcus constellatus competence stimulating peptide (CSP) analogs with enhanced potencies were developed. These newly identified CSP analogs provide a rational framework for the development of CSP‐based quorum sensing modulators with translational potential in attenuating virulence processes in this ...
Keely M. Rodriguez, Daniel N. Elliott, Ella R. Lemieux, Oscar S. Liu, Yftah Tal‐Gan   +4 more
wiley   +1 more source

The Putative Virulence Plasmid pYR4 of the Fish Pathogen Yersinia ruckeri Is Conjugative and Stabilized by a HigBA Toxin-Antitoxin System. [PDF]

Biology (Basel)
Floras F, Mawere C, Singh M, Wootton V, Hamstead L, McVicker G, Leo JC.   +6 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, Volume 16, Issue 7, Page 1271-1292, July 2026.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Virulence plasmid with IroBCDN deletion promoted cross-regional transmission of ST11-KL64 carbapenem-resistant hypervirulent Klebsiella pneumoniae in central China. [PDF]

BMC Microbiol
Hong HX, Huo BH, Xiang TX, Wei DD, Huang QS, Liu P, Zhang W, Xu Y, Liu Y.   +8 more
europepmc   +1 more source

Dietary Polyphenols as Natural Modulators of NF‐κB Signaling in Inflammation‐Driven Non‐Communicable Diseases: Focus on Cancer

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Dietary polyphenols and phytochemicals suppress NF‐κB signaling. Mechanistically, by inhibiting IκBα degradation and preventing nuclear translocation of p65/p50 complexes, the polyphenols reduce the expression of pro‐inflammatory and pro‐survival genes, thereby decreasing overall cancer cell survival.
Khuzin Dinislam, Anas Shamsi, Syed Tasqeruddin, Moyad Shahwan   +3 more
wiley   +1 more source