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The Salmonella Typhimurium Virulence Plasmid
1991Salmonellosis is a good example of an infectious disease in which intracellular growth is an essential step; Salmonellae undergo a major multiplication step within host tissue macrophages. Many different serovars of Salmonella cause extraintestinal infections in man and mouse, yet the course of the infection is similar, if not identical.
Mikael Rhen +4 more
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Molecular analysis of spv virulence genes of the salmonella virulence plasmids
Molecular Microbiology, 1993SummaryGenes on an 8 kb region common to the virulence plasmids of several serovars of Salmonella are sufficient to replace the entire plasmid in enabling systemic infection in animal models. This virulence region encompasses five genes which previously have been designated with different names from each investigating laboratory.
P A, Gulig +5 more
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Plasmid Encoded Virulence of Yersinia
1991The three virulent members of the genus Yersinia harbour related virulence Plasmids with a molecular weight of about 60-70 kb (11). When exponential phase cultures of these organisms growing in a Ca2+ free medium are shifted from 26C to 37C, growth ceases over a period of about 2 generations (10).
H. Wolf-Watz +8 more
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Effect of Plasmid Carriage on the Virulence of Staphylococcus Aureus
Journal of Medical Microbiology, 1975The possession of any of eight different plasmids by Staphylococcus aureus strain 649--either singly or simultaneously (in no. 649MR)--caused changes in growth kinetics. Six of the plasmids caused an increase in exponential doubling time (by 8-25%), and most also altered the duration of the lag period.
R W, Lacey, I, Chopra
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Plasmid-induced loss of virulence in Vibrio cholerae
Nature, 1978WE have previously reported that pathogenicity of Vibrio cholerae was suppressed by introducing P or V plasmids and that this effect was due to decreased toxin production1. This work has been extended to show that cells harbouring both P and V plasmids become attenuated and do not cause experimental cholera.
V B, Sinha, B S, Srivastava
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Salmonella typhimurium Bacteremia: Association with the Virulence Plasmid
Journal of Infectious Diseases, 1992Virulence plasmids, which are found in a small number of Salmonella serotypes, greatly enhance the extraintestinal growth of salmonellae and lower the LD50 by 2-5 logs in experimental murine infections. To determine if virulence plasmids are important in the pathogenesis of Salmonella bacteremia in humans, blood and fecal isolates of Salmonella ...
J, Fierer +3 more
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2014
This chapter discusses the genome-scale analysis of virulence plasmids: the contribution of plasmid-borne virulence genes to enterobacterial pathogenesis. The spectrum of diseases caused by Escherichia coli and other enteric bacteria is due to the acquisition of a variety of specific virulence genes harbored on plasmids, on bacteriophages, or within ...
Malabi M. Venkatesan, Valerie Burland
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This chapter discusses the genome-scale analysis of virulence plasmids: the contribution of plasmid-borne virulence genes to enterobacterial pathogenesis. The spectrum of diseases caused by Escherichia coli and other enteric bacteria is due to the acquisition of a variety of specific virulence genes harbored on plasmids, on bacteriophages, or within ...
Malabi M. Venkatesan, Valerie Burland
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The Virulence Plasmids of Shigella flexneri
2009Shigella species and enteroinvasive Escherichia coli possess a large virulence plasmid that carries the genes necessary for invasion and colonization of the epithelial cell layer of the human gut resulting in dysentery. The plasmid is a hybrid molecule with a complex evolutionary history.
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[The "side-effects" of plasmids (R-plasmids and virulence)].
Molekuliarnaia genetika, mikrobiologiia i virusologiia, 1987Many plasmids affect the host cells. Their effects cannot be explained only by the expression of the well-known genes coding for antibioticresistance, bacteriocinogeny and hemolysis or the analogous genes (side-effects). The side effects are not characteristic of all plasmids operating under similar conditions.
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