Results 171 to 180 of about 171,270 (316)

Plasmid Genomic Dynamics and One Health: Drivers of Antibiotic Resistance and Pathogenicity

open access: yesPathogens
Seen through a One Health perspective, plasmids act as global links, connecting human, animal, and environmental microbiomes while broadening the ecological scope of resistance and virulence. By combining knowledge about plasmid classification, mobility,
Célia P. F. Domingues   +3 more
doaj   +1 more source

Acquisition of a large virulence plasmid (pINV) promoted temperature-dependent virulence and global dispersal of O96:H19 enteroinvasive <i>Escherichia coli</i>. [PDF]

open access: yesmBio, 2023
Miles SL   +8 more
europepmc   +1 more source

Typhoid Toxin of Salmonella enterica Induces ISG15 Responses Mediating Host Cell Survival and Counteracting Intracellular Infection

open access: yesMolecular Microbiology, EarlyView.
Toxigenic Salmonella enterica exocytose the typhoid toxin during infection causing host cell DNA damage, which activates a Type‐1 Interferon‐like response characterised by interferon‐stimulated gene 15 (ISG15) expression. ISG15 was required for host cell survival during Interferon responses and suppressed intracellular growth of Salmonella. Thus, ISG15
Daniel S. Stark   +11 more
wiley   +1 more source

An Escherichia coli Phosphotransferase System Modulates Methylglyoxal Resistance by Regulating Intracellular Potassium

open access: yesMolecular Microbiology, EarlyView.
Escherichia coli can survive methylglyoxal stress by modulating phosphorylation of a regulatory phosphotransferase system, which, in turn, regulates the activity of a potassium/proton antiporter. The constitutive potassium importer Trk also contributes to intracellular potassium levels.
Sara Alexander, Mark Goulian
wiley   +1 more source

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

open access: yesMolecular Microbiology, EarlyView.
Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall‐targeting antimicrobials, combining RNAseq and high‐resolution tiling arrays. We revealed the complexity of the CESR, the contribution of extracytoplasmic function sigma factors (ECFs) and two‐component signal transduction ...
Qian Zhang   +12 more
wiley   +1 more source

Large scale expansion of mobile elements in specific hotspot regions of the German outbreak _Escherichia coli_ O104:H4 [PDF]

open access: yes, 2011
The outbreak strain of _E. coli_ O104:H4 has been sequenced by several groups and made available publicly for CrowdSourcing purposes. Genome comparisons of the complete finished sequence of TY2482 (BGI), have been made with the draft assemblies of ...
Lisa C. Crossman
core   +1 more source

Redundant and Flexible Electron Transfer Pathways Underlie MsrPQ‐Mediated Repair of Oxidized Periplasmic Proteins

open access: yesMolecular Microbiology, EarlyView.
This study investigates in vivo the role of the flavin reductase Fre as an electron supplier to the periplasmic methionine sulfoxide reductase system MsrPQ. ABSTRACT The MsrPQ system is essential for the repair of oxidized methionine residues in periplasmic proteins, ensuring bacterial resistance to oxidative stress and envelope integrity.
Laurent Loiseau, Benjamin Ezraty
wiley   +1 more source

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