Pleiotropic roles of the MATE transporter CD20030 in Clostridioides difficile: linking multidrug resistance to oxidative stress defense and virulence regulation [PDF]
Frontiers in MicrobiologyBackgroundThe multidrug-resistant pathogen Clostridioides difficile (C. difficile) presents a persistent clinical threat. While Multidrug and Toxic Compound Extrusion (MATE) transporters are recognized as xenobiotic efflux pumps, their pleiotropic roles ...
Jie Deng +8 more
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Streptococcus pyogenes (“Group A Streptococcus”), a Highly Adapted Human Pathogen—Potential Implications of Its Virulence Regulation for Epidemiology and Disease Management [PDF]
Pathogens, 2021 Streptococcus pyogenes (group A streptococci; GAS) is an exclusively human pathogen. It causes a variety of suppurative and non-suppurative diseases in people of all ages worldwide. Not all can be successfully treated with antibiotics. A licensed vaccine,
Nikolai Siemens, Rudolf Lütticken
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MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation [PDF]
Cell Host and Microbe, 2023 Richard Copin +2 more
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Vibrio cholerae’s ToxRS bile sensing system
eLife, 2023 The seventh pandemic of the diarrheal cholera disease, which began in 1960, is caused by the Gram-negative bacterium Vibrio cholerae. Its environmental persistence provoking recurring sudden outbreaks is enabled by V.
Nina Gubensäk +14 more
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The global role of Lrp in Vibrio alginolyticus and its response to diverse physicochemical factors
Frontiers in Marine Science, 2022 Leucine-responsive regulatory protein (Lrp) is an essential transcriptional regulator in prokaryotes. However, the regulatory role of lrp in Vibrio alginolyticus has still not been studied in detail. In this study, an lrp mutant strain was constructed to
Wenxiao Su +6 more
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mBio, 2022 The interactions between the gut microbiota and pathogens are complex and can determine the outcome of an infection. Enterohemorrhagic Escherichia coli (EHEC) is a major human enteric pathogen that colonizes the colon through attaching and effacing (AE ...
Fernando H. Martins +5 more
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Control of Bacterial Virulence through the Peptide Signature of the Habitat
Cell Reports, 2019 Summary: To optimize fitness, pathogens selectively activate their virulence program upon host entry. Here, we report that the facultative intracellular bacterium Listeria monocytogenes exploits exogenous oligopeptides, a ubiquitous organic N source, to ...
Emilia Krypotou +6 more
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Differential Afa/Dr Fimbriae Expression in the Multidrug-Resistant Escherichia coli ST131 Clone
mBio, 2022 Many antibiotic resistant uropathogenic Escherichia coli (UPEC) strains belong to clones defined by their multilocus sequence type (ST), with ST131 being the most dominant.
Laura Alvarez-Fraga +13 more
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Expression of colSR Genes Increased in the rpf Mutants of Xanthomonas oryzae pv. oryzae KACC10859
The Plant Pathology Journal, 2014 The rpf genes and colSXOO1207/colRXOO1208 were known to require for virulence of Xanthomonas oryzae pv. oryzae (Xoo). In Xoo KACC10331 genome, two more colS/colR genes, colSXOO3534 (raxH)/colRXOO3535 (raxR) and colSXOO3762/colRXOO3763 were annotated. The
Young-Hee Noh +4 more
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A long-term epigenetic memory switch controls bacterial virulence bimodality
eLife, 2017 When pathogens enter the host, sensing of environmental cues activates the expression of virulence genes. Opposite transition of pathogens from activating to non-activating conditions is poorly understood.
Irine Ronin +3 more
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