Results 11 to 20 of about 502,614 (287)

ITN—VIROINF: Understanding (Harmful) Virus-Host Interactions by Linking Virology and Bioinformatics

Viruses, 2021
Many recent studies highlight the fundamental importance of viruses. Besides their important role as human and animal pathogens, their beneficial, commensal or harmful functions are poorly understood.
Winfried Goettsch, Niko Beerenwinkel, Li Deng, Lars Dölken, Bas E. Dutilh, Florian Erhard, Lars Kaderali, Max von Kleist, Roland Marquet, Jelle Matthijnssens, Shawna McCallin, Dino McMahon, Thomas Rattei, Ronald P. Van Rij, David L. Robertson, Martin Schwemmle, Noam Stern-Ginossar, Manja Marz   +17 more
doaj   +1 more source

Regulatory Role of Host MicroRNAs in Flaviviruses Infection

Frontiers in Microbiology, 2022
MicroRNAs (miRNAs) are small non-coding RNA that affect mRNA abundance or translation efficiency by binding to the 3′UTR of the mRNA of the target gene, thereby participating in multiple biological processes, including viral infection.
Wenjun Cai, Wenjun Cai, Wenjun Cai, Yuhong Pan, Yuhong Pan, Yuhong Pan, Anchun Cheng, Anchun Cheng, Anchun Cheng, Mingshu Wang, Mingshu Wang, Mingshu Wang, Zhongqiong Yin, Renyong Jia, Renyong Jia, Renyong Jia   +15 more
doaj   +1 more source

Bioinformatics approaches for unveiling virus-host interactions

Computational and Structural Biotechnology Journal, 2023
The coronavirus disease-2019 (COVID-19) pandemic has elucidated major limitations in the capacity of medical and research institutions to appropriately manage emerging infectious diseases.
Hitoshi Iuchi, Junna Kawasaki, Kento Kubo, Tsukasa Fukunaga, Koki Hokao, Gentaro Yokoyama, Akiko Ichinose, Kanta Suga, Michiaki Hamada   +8 more
doaj   +1 more source

VP24-Karyopherin alpha binding affinities differ between Ebolavirus species, nfluencing interferon inhibition and VP24 stability [PDF]

, 2017
Zaire ebolavirus (EBOV), Bundibugyo ebolavirus (BDBV), and Reston ebolavirus (RESTV) belong to the same genus but exhibit different virulence properties.
Alinger, Joshua B, Amarasinghe, Gaya K, Basler, Christopher F, Diederichs, Audrey, Edwards, Megan R, Leung, Daisy W, Schwarz, Toni M   +6 more
core   +2 more sources

Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host [PDF]

, 2013
Schmallenberg virus (SBV) is an emerging orthobunyavirus of ruminants associated with outbreaks of congenital malformations in aborted and stillborn animals.
A Bridgen, A Bridgen, A Kohl, AC Lowen, AJ Della-Porta, Alain Kohl, Andrew Shaw, Anna Janowicz, AR Elbers, B Hoffmann, B Xu, CA Evans, Catherine Lamm, Claudio Murgia, CM Southam, CT Walter, D Thomas, DH Cybinski, Esther Schnettler, Eva McGregor, F Arnaud, Friedemann Weber, G Barry, G Blakqori, G Blakqori, G Neumann, Gerald Barry, Ilaria M. Piras, JI Gillespie, JL Farmer, K Kupferschmidt, K Peperkamp, K Terasaki, K Wernike, KE Jones, Kerstin Hahn, KV Goller, LD Rasmussen, M Beer, M Bouloy, M Caporale, M Dominguez, M Palmarini, M Ratinier, M Spiegel, M Varela, Mandy Glass, Marco Caporale, Mariana Varela, Martin Beer, Massimo Palmarini, Melanie McFarlane, MJ Killip, MM Garigliany, MM Garigliany, NR Saunders, OR Causey, P Vialat, PJ Hotez, PT Leisnham, R Muller, RS Azevedo, S Shimshony, SE Randolph, T Ikegami, T Yanase, UJ Buchholz, V Herder, Vanessa Herder, VH Leonard, Wolfgang Baumgärtner, X Shi, Y Ogawa, YK Liao   +73 more
core   +7 more sources

Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]

, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel, Kasvandik, Sergo, Lulla, Aleksei, Lulla, Valeria, McInerney, Gerald M., Merits, Andres, Morro, Ainhoa Moliner, Mutso, Margit, Saul, Sirle, Smedberg, Cecilia, Tarve, Liisi, Teppor, Mona, Thaa, Bastian, Varjak, Margus   +13 more
core   +6 more sources

Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication

Virology Journal, 2017
Background The rapid rise and spread in dengue cases, together with the unavailability of safe vaccines and effective antiviral drugs, warrant the need to discover and develop novel anti-dengue treatments. In this study the antiviral activity of geraniin,
Siti Aisyah Abdul Ahmad, Uma D. Palanisamy, Bimo A. Tejo, Miaw Fang Chew, Hong Wai Tham, Sharifah Syed Hassan   +5 more
doaj   +1 more source

Dynamical correlations in the escape strategy of Influenza A virus [PDF]

, 2013
The evolutionary dynamics of human Influenza A virus presents a challenging theoretical problem. An extremely high mutation rate allows the virus to escape, at each epidemic season, the host immune protection elicited by previous infections.
Colaiori, Francesca, Loreto, Vittorio, Taggi, Lorenzo, Tria, Francesca   +3 more
core   +1 more source

CPB1 of Aedes aegypti Interacts with DENV2 E Protein and Regulates Intracellular Viral Accumulation and Release from Midgut Cells

Viruses, 2014
Aedes aegypti is a principal vector responsible for the transmission of dengue viruses (DENV). To date, vector control remains the key option for dengue disease management.
Hong-Wai Tham, Vinod R. M. T. Balasubramaniam, Bimo Ario Tejo, Hamdan Ahmad, Sharifah Syed Hassan   +4 more
doaj   +1 more source

Receptors for Respiratory Syncytial Virus Infection and Host Factors Regulating the Life Cycle of Respiratory Syncytial Virus

Frontiers in Cellular and Infection Microbiology, 2022
Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections and responsible for a large proportion of mortality in children and the elderly. There are no licensed vaccines available to date.
Ziheng Feng, Ziheng Feng, Lili Xu, Lili Xu, Zhengde Xie, Zhengde Xie   +5 more
doaj   +1 more source