Host restriction factors in retroviral infection: promises in virus-host interaction
Retrovirology, 2012 Retroviruses have an intricate life cycle. There is much to be learned from studying retrovirus-host interactions. Among retroviruses, the primate lentiviruses have one of the more complex genome structures with three categories of viral genes ...
Zheng Yong-Hui +2 more
doaj +1 more source
mSystems, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-strand RNA virus. The viral genome is capped at the 5′ end, followed by an untranslated region (UTR). There is a poly(A) tail at the 3′ end, preceded by a UTR.
Rohit Verma +5 more
doaj +1 more source
Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors [PDF]
, 2010 Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined.
Bitzegeio, Julia +10 more
core +2 more sources
Sensing the danger in mosquito spit
The EMBO JournalFactors contained within mosquito saliva enhance transmission of mosquito-borne viruses to the mammalian host. In this issue, Wang et al (2024) identify AaNRP as a crucial pro-viral factor in Aedes aegypti mosquito saliva that promotes recruitment of ...
Yonca Keskek Turk +2 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Recognition of human oncogenic viruses by host pattern recognition receptors
Frontiers in Immunology, 2014 Human oncogenic viruses include Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1), Kaposi’s associated sarcoma virus (KSHV), and Merkel cell polyomavirus ...
Nelson C Di Paolo
doaj +1 more source
An insect virus-encoded microRNA regulates viral replication [PDF]
, 2008 MicroRNAs (miRNAs) are important regulators of biological processes, including host-virus interaction. This study investigated the involvement of Drosophila melanogaster miR-8-5p in host-virus interaction.
Hussain, Mazhar +2 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Surprising Complexity of Virus-Host Cell Interaction Revealed by the Powerful Systems Biology Approaches of Genomics and Proteomics [PDF]
, 2013 Understanding interaction between viruses and host cells during infection process is the first step in discovering appropriate drugs and vaccines against viral diseases. Advance technologies based on genomics and proteomics approaches provide great tools
Rustanti, L. (Lina)
core +1 more source
Sand fly saliva reprograms skin fibroblasts to enhance arbovirus infection
iScienceSummary: Arbovirus transmission by sand flies is a growing public health concern, yet the early skin events shaping infection outcomes remain undefined.
Yonca Keskek Turk +12 more
doaj +1 more source