Results 221 to 230 of about 10,857,229 (262)

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Association of Helicobacter pylori and Epstein-Barr virus co-infection in gastric cancer patients: a prospective analytical study. [PDF]

Arq Bras Cir Dig
Sivamoorthy A, Sureshkumar S, Anandhi A, Dhodapkar R, Chinnakali P, Kate V.   +5 more
europepmc   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Sudden suspected anaphylactic shock after multiple tolerated doses of piperacillin-tazobactam: a case report and literature review. [PDF]

Front Med (Lausanne)
Li P, Yu H, Mo X, Liu L, Liu C, Zhang Z, Yan M.   +6 more
europepmc   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Hepatitis B and D burden in Uzbekistan: comprehensive analysis of seroprevalence and risk correlates from a countrywide study. [PDF]

Infect Dis Poverty
Musabaev EI, Khodjaeva ME, Khikmatullaeva AS, Ibadullaeva NS, Shodieva FSK, Khudaykulova GK, Tadjieva NU, Amonov SB, Mirzaev UK.   +8 more
europepmc   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

An in-hospital referral program for hepatitis C virus elimination in patients with type 2 diabetes mellitus. [PDF]

J Chin Med Assoc
Chi CT, Wu TH, Lee PC, Su GY, Chen TY, Lee IC, Hou MC, Hwu CM, Huang YH.   +8 more
europepmc   +1 more source

Variations in the viral hepatitis C prevalence and treatment status by material hardship and cumulative risk among people who inject drugs. [PDF]

Drug Alcohol Depend Rep
Ganesh SS, Trigo DR, Smeltzer RP, Ward C, Orta Portillo GA, Gonzalez KD, Sannareddy S, Conner BT, Bluthenthal RN.   +8 more
europepmc   +1 more source

Nanoparticles for antiviral nucleotide analogs: approaches and analytical challenges. [PDF]

J Virol
Clifford SM, Edwards MJ, Krittaphol W, Walker GF, Harris LD, Ward VK.   +5 more
europepmc   +1 more source