Results 231 to 240 of about 10,857,229 (262)

IFITM3 at the viral fusion-pore checkpoint: membrane energetics and entry-route-dependent outcomes. [PDF]

Front Immunol
Mao L, Wang S, Bai Y, Cheng S, Gao K, Chang Y, Li L, Guo Y, Gao M.   +8 more
europepmc   +1 more source

Influenza A and other respiratory viruses show distinct associations with acute respiratory presentations and temporal correlation with hospital admissions. [PDF]

J Med Microbiol
Husein M, Samara M, Alfarra MR, Al-Kinani A, Al-Dewik N, Coyle PV.   +5 more
europepmc   +1 more source

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Characterization of Virus Particles and Submicron-Sized Particulate Impurities in Recombinant Adeno-Associated Virus Drug Product

Journal of Pharmaceutical Sciences, 2023
Characterization of particulate impurities such as aggregates is necessary to develop safe and efficacious adeno-associated virus (AAV) drug products. Although aggregation of AAVs can reduce the bioavailability of the virus, only a limited number of studies focus on the analysis of aggregates.
Cornelia Hiemenz, Anabel Pacios-Michelena, Constanze Helbig, Valerija Vezočnik, Michael Strebl, Felix Nikels, Andrea Hawe, Patrick Garidel, Tim Menzen   +8 more
openaire   +2 more sources

Hypoglycemia associated with direct‐acting anti‐hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS)

Clinical Endocrinology, 2021
AbstractBackground and ObjectiveHypoglycemia induced by direct‐acting antiviral agents (DAAs) for chronic hepatitis C virus (HCV) infection is a rare but potentially life‐threatening adverse reaction, which led to warnings by competent authorities. We therefore aimed to examine the hypoglycemic safety signal for DAAs.MethodsReports to the US Food and ...
Yu, Zhou, Wenhuo, Xie, Chenhua, Zheng, Libin, Liu, Zhou, Chen, Xiaolu, Wang   +5 more
openaire   +2 more sources

Hepatitis C virus drug resistance associated substitutions and their clinical relevance: Update 2018

Drug Resistance Updates, 2018
Nowadays, due to the development of potent Direct-Acting Antiviral Agents (DAAs) that specifically target NS3, NS5A and NS5B viral proteins, several new and highly efficacious options to treat chronic Hepatitis C virus (HCV) infection are available. The natural presence of resistance associated substitutions (RASs), as well as their rapid emergence ...
Sorbo M. C., Cento V., Di Maio V. C., Howe A. Y. M., Garcia F., Perno C. F., Ceccherini-Silberstein F.   +6 more
openaire   +3 more sources

Effects of resistance‐associated variants in genotype 2 hepatitis C virus on viral replication and susceptibility to antihepatitis C virus drugs

Hepatology Research, 2019
AimsDevelopment of direct‐acting antivirals (DAAs) has made antihepatitis C virus (HCV) treatment highly safe and effective. However, the emergence of resistant‐associated variants (RAVs) after failure of DAA therapy affects retreatment outcomes. In particular, genotype 1 HCV with P32 deletion has been reported to be highly resistant to all approved ...
Goki Suda, Megumi Kimura, Taku Shigesawa, Kazuharu Suzuki, Akihisa Nakamura, Masatsugu Ohara, Naoki Kawagishi, Masato Nakai, Takuya Sho, Osamu Maehara, Tomoe Shimazaki, Kenichi Morikawa, Mitsuteru Natsuizaka, Koji Ogawa, Naoya Sakamoto   +14 more
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Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b HCV with drug resistance-associated variants in prior DAA treatment failures and human hepatocyte transplanted mice 1.Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures 2.Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice [PDF]

, 2020
内容の要旨 ...
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Cervical cancer prevention and control in women living with human immunodeficiency virus

Ca-A Cancer Journal for Clinicians, 2021
Vikrant V Sahasrabuddhe, Philip E Castle, Mark H Einstein   +2 more
exaly