Results 241 to 250 of about 421,443 (284)

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

A New Type of Nonsuppressible Viremia Produced by HIV-Infected Macrophage. [PDF]

J Infect Dis
Moeser MJ, Council OD, Long N, Kincer L, Dennis AM, Eron J, Wohl D, Farel CE, Dittmer DP, Pluta L, Nelson J, Mohammadi A, Etemad B, Li JZ, McGann H, Smit E, Clement M, Yau T, Menezes P, Bowman NM, Zhou S, Joseph SB.   +21 more
europepmc   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

The Association Between Receiving Medications for Opioid Use Disorder and Human Immunodeficiency Virus Testing: Findings From the Rural Opioid Initiative. [PDF]

J Addict Med
Zinsli KA, Mixson LS, Delaney JA, Feinberg J, Stopka TJ, Seal DW, Smith GS, Pho MT, Wu EL, Jenkins W, Cooper HLF, Young AM, Khoury D, Friedmann PD, Miller WC, Go VF, Korthuis PT, Spencer H, Westergaard RP, Tsui JI.   +19 more
europepmc   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Surface Plasmon Resonance as a Tool in Antiviral Drug Discovery Research. [PDF]

Biosensors (Basel)
Wegrzyn KE, Matsoukas JM.
europepmc   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Portal Vein Thrombosis Due to Concomitant Cytomegalovirus and Epstein-Barr Virus Infection: An Underestimated Complication. [PDF]

Am J Case Rep
AlQahtani SY.
europepmc   +1 more source

An Analysis of UK Drug Policy [PDF]

, 2007
Stevens, Alex, Reuter, Peter
core  

MOGAD optic neuritis post enterovirus meningitis: a new association. [PDF]

BMJ Neurol Open
Aljarallah S, Aldraihem OO, Alqarni K.
europepmc   +1 more source