Results 51 to 60 of about 253,283 (242)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Targeting Virus-host Interactions of HIV Replication

Current Topics in Medicinal Chemistry, 2015
Cellular proteins that are hijacked by HIV in order to complete its replication cycle, form attractive new targets for antiretroviral therapy. In particular, the protein-protein interactions between these cellular proteins (cofactors) and viral proteins are of great interest to develop new therapies.
Weydert, Caroline, De Rijck, Jan, Christ, Frauke, Debyser, Zeger   +3 more
openaire   +2 more sources

Hepatitis C virus–host cell interactions uncovered [PDF]

Proceedings of the National Academy of Sciences, 2007
Insights into virus–host cell interactions as uncovered by Randall et al. (1) in a recent issue of PNAS further our understanding of the hepatitis C virus (HCV) life cycle, persistence, and pathogenesis and might lead to the identification of new therapeutic targets. HCV persistently infects 180 million individuals worldwide, causing chronic hepatitis,
Judith M, Gottwein, Jens, Bukh
openaire   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

A 28-Year History of HIV-1 Drug Resistance and Transmission in Washington, DC

Frontiers in Microbiology, 2019
Washington, DC consistently has one of the highest annual rates of new HIV-1 diagnoses in the United States over the last 10 years. To guide intervention and prevention strategies to combat DC HIV infection, it is helpful to understand HIV transmission ...
Keylie M. Gibson, Margaret C. Steiner, Seble Kassaye, Frank Maldarelli, Zehava Grossman, Zehava Grossman, Marcos Pérez-Losada, Marcos Pérez-Losada, Marcos Pérez-Losada, Keith A. Crandall, Keith A. Crandall   +10 more
doaj   +1 more source

A systems biology-driven approach to construct a comprehensive protein interaction network of influenza A virus with its host

BMC Infectious Diseases, 2020
Background Influenza A virus (IAV) infection is a serious public health problem not only in South East Asia but also in European and African countries.
Qurat ul Ain Farooq, Zeeshan Shaukat, Sara Aiman, Tong Zhou, Chunhua Li   +4 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Killer Archaea: Virus-Mediated Antagonism to CRISPR-Immune Populations Results in Emergent Virus-Host Mutualism

mBio, 2020
Theory, simulation, and experimental evolution demonstrate that diversified CRISPR-Cas immunity to lytic viruses can lead to stochastic virus extinction due to a limited number of susceptible hosts available to each potential new protospacer escape ...
Samantha J. DeWerff, Maria A. Bautista, Matthew Pauly, Changyi Zhang, Rachel J. Whitaker   +4 more
doaj   +1 more source

Protein–Protein Interactions in Virus–Host Systems [PDF]

Frontiers in Microbiology, 2017
To study virus-host protein interactions, knowledge about viral and host protein architectures and repertoires, their particular evolutionary mechanisms, and information on relevant sources of biological data is essential. The purpose of this review article is to provide a thorough overview about these aspects.
Brito, AF, Pinney, JW
openaire   +5 more sources