Results 71 to 80 of about 722,631 (394)

Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine

Scientific Reports, 2017
The leading malaria vaccine in development is the circumsporozoite protein (CSP)-based particle vaccine, RTS,S, which targets the pre-erythrocytic stage of Plasmodium falciparum infection.
K. Collins, R. Snaith, Matthew G. Cottingham, S. Gilbert, A. Hill   +4 more
semanticscholar   +1 more source

Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity [PDF]

, 2021
Cyclic GMP-AMP (cGAMP) is an immunostimulatory molecule produced by cGAS that activates STING. cGAMP is an adjuvant when administered alongside antigens. cGAMP is also incorporated into enveloped virus particles during budding.
Beveridge, Ryan, Borrow, Persephone, Bridgeman, Anne, Chauveau, Lise, Drakesmith, Hal, Frost, Joe N, Gilbert-Jaramillo, Javier, Knight, Michael L, Liu, Xu, Partridge, Thomas, Pedroza-Pacheco, Isabela, Rehwinkel, Jan, Rijal, Pramila, Russell, Rebecca A, Tan, Tiong K, Townsend, Alain R   +15 more
core   +2 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

High-speed imaging of ESCRT recruitment and dynamics during HIV virus like particle budding.

PLoS ONE, 2020
Endosomal sorting complexes required for transport proteins (ESCRT) catalyze the fission of cellular membranes during budding of membrane away from the cytosol.
Shilpa Gupta, Josh Bromley, Saveez Saffarian   +2 more
doaj   +1 more source

Investigation of the particle-particle interaction effects in the cosmic Zevatron based on cyclotron auto-resonance by particle-in-cell simulations [PDF]

arXiv, 2021
Cyclotron autoresonance acceleration has been recently advanced as a potential mechanism for accelerating nuclei to ZeV energies (1 ZeV = $10^{21}$ eV). All results have been based on single- and many-particle calculations employing analytic solutions to the relativistic equations of motion in the combined magnetic and radiation fields, excluding ...
arxiv  

Virus-like particles as vaccine adjuvants

Molecular Biotechnology, 2001
Virus-like particles (VLPs) consist of one or more viral coat proteins that assemble into particles. They can be taken up by antigen presenting cells (APC), peptides derived from them are presented on MHC class I molecules at the cell surface, and thereby prime a CD8+ T cell response, either against the particle-forming protein itself (such as ...
openaire   +4 more sources

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

Molecular Oncology, EarlyView.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, Maria J Barrero, Diego Megías, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez‐Dominguez, Sara Monzón, Isabel Cuesta, Laura Sánchez, Rodrigo Barderas, Jesús García‐Donas, Alberto Martín, Ignacio Pérez de Castro   +17 more
wiley   +1 more source

Effective chikungunya virus-like particle vaccine produced in insect cells. [PDF]

PLoS Neglected Tropical Diseases, 2013
The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful
Stefan W Metz, Joy Gardner, Corinne Geertsema, Thuy T Le, Lucas Goh, Just M Vlak, Andreas Suhrbier, Gorben P Pijlman   +7 more
doaj   +1 more source

Recombinant Virus-like Particles of Human Parvovirus B19 with the Internal Location of VP1 Unique Region Produced by Hansenula polymorpha

Viruses, 2022
Human parvovirus B19 (HPV B19) is pathogenic to human, which can cause fifth disease, transient aplastic crisis, arthritis, myocarditis, autoimmune disorders, hydrops fetalis, and so on.
Shuai Shao, Qingqing Wang, Yuqin Jin, Xuefeng Zhang, Zhaoming Liu, Shi Chen, Hailan Wu, Sensen Yang, Fang Tang, Jiguo Su, Yu Liang, Jing Zhang, Qiming Li   +12 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source