Results 51 to 60 of about 6,712,945 (253)

Interaction between long and short particles of tobacco rattle virus [PDF]

, 1972
Tobacco rattle virus is a rod-shaped multiparticle virus.Short particles alone are not infectious, long ones are but give rise to the formation of incomplete virus. Mixtures of long and short particles induce the formation of complete virus.
Huttinga, H.
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Virus-inspired biogenic delivery system for advancing cancer therapy

Biomedical Technology
Virus-inspired particles have been utilized in various applications, including vaccination, gene therapy, drug therapy, and diagnostics. Biogenic delivery systems imitating the natural structure of viruses are regarded as innovative nanoplatforms used to
Di Sun, Hao Liang, Qianwen Mu, Chengchao Chu, Gang Liu, Chao Liu   +5 more
doaj   +1 more source

Establishment of a yeast-based VLP platform for antigen presentation

Microbial Cell Factories, 2018
Background Chimeric virus-like particles (VLP) allow the display of foreign antigens on their surface and have proved valuable in the development of safe subunit vaccines or drug delivery.
David Wetzel, Theresa Rolf, Manfred Suckow, Andreas Kranz, Andreas Barbian, Jo-Anne Chan, Joachim Leitsch, Michael Weniger, Volker Jenzelewski, Betty Kouskousis, Catherine Palmer, James G. Beeson, Gerhard Schembecker, Juliane Merz, Michael Piontek   +14 more
doaj   +1 more source

Cell-free protein synthesis of norovirus virus-like particles [PDF]

, 2017
Cell-free protein expression of norovirus virus-like-particles.
Xueyang Feng, Sheng, Jiayuan, Shaohua Lei, Lijuan Yuan, Jiayuan Sheng, Lei, Shaohua, Yuan, Lijuan, Feng, Xueyang   +7 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

RNA transmission and expression from inert HIV candidate vaccine virus-like-particles [PDF]

, 2008
Includes abstract.Includes bibliographical references (leaves 136-158).HIV-1 Gag virus-like-particles (VLPs) produced in various expression systems are potent stimulators of both cellular and humoral immune responses in animal models.
Valley-Omar, Ziyaad
core   +1 more source

Preclinical Development of a Novel Zika Virus-like Particle Vaccine in Combination with Tetravalent Dengue Virus-like Particle Vaccines

Vaccines
Declared as a Public Health Emergency in 2016 by the World Health Organization (WHO), the Zika virus (ZIKV) continues to cause outbreaks that are linked to increased neurological complications.
Dominik A. Rothen, Sudip Kumar Dutta, Pascal S. Krenger, Alessandro Pardini, Anne-Cathrine S. Vogt, Romano Josi, Ilva Lieknina, Albert D. M. E. Osterhaus, Mona O. Mohsen, Monique Vogel, Byron Martina, Kaspars Tars, Martin F. Bachmann   +12 more
doaj   +1 more source

Virus-Like Particles as an Immunogenic Platform for Cancer Vaccines

Viruses, 2020
Virus-like particles (VLP) spontaneously assemble from viral structural proteins. They are naturally biocompatible and non-infectious. VLP can serve as a platform for many potential vaccine epitopes, display them in a dense repeating array, and elicit ...
Jerri C. Caldeira, Michael Perrine, Federica Pericle, Federica Cavallo   +3 more
doaj   +1 more source