Results 61 to 70 of about 6,712,945 (253)

Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj [PDF]

, 2009
Background: Human primary monocytes are refractory to infection with the human immunodeficiency virus 1 (HIV-1) or transduction with HIV-1-derived vectors.
Kaiser, Julia, Schüle Silke, Wolfrum, Nina, Heidmeier Sabine, Sylvia Panitz, Julia K Kaiser, Panitz Sylvia, Klaus Cichutek, Silke Schüle, Heidmeier, Sabine, Kaiser Julia K., Schweizer, Matthias, Cichutek Klaus, Schüle, Silke, Kloke, Björn-Philipp, Matthias Schweizer, Wolfrum Nina, Panitz, Sylvia, Sabine Heidmeier, Cichutek, Klaus, Nina Wolfrum, Kloke Björn-Philipp, Schweizer Matthias, Björn-Philipp Kloke   +23 more
core   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Production in yeast of pseudotype virus-like particles harboring functionally active antibody fragments neutralizing the cytolytic activity of vaginolysin

Microbial Cell Factories, 2011
Background Recombinant antibodies can be produced in different formats and different expression systems. Single chain variable fragments (scFvs) represent an attractive alternative to full-length antibodies and they can be easily produced in bacteria or ...
Pleckaityte Milda, Zvirbliene Aurelija, Sezaite Indre, Gedvilaite Alma   +3 more
doaj   +1 more source

Author Correction: Minimal system for assembly of SARS-CoV-2 virus like particles

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Heather Swann, Abhimanyu Sharma, Benjamin Preece, Abby Peterson, Crystal Eldredge, David M. Belnap, Michael Vershinin, Saveez Saffarian   +7 more
doaj   +1 more source

Cryotomography of budding influenza a virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end [PDF]

, 2013
Influenza viruses exhibit striking variations in particle morphology between strains. Clinical isolates of influenza A virus have been shown to produce long filamentous particles while laboratory-adapted strains are predominantly spherical.
Swetha Vijayakrishnan, Vijayakrishnan Swetha, Jackson David, Worawit Suphamungmee, David Bhella, Loney Colin, Bhella, D., Swetha Vijayakrishnan (418947), Colin Loney (418948), David Jackson (84936), Frazer J. Rixon (129686), Colin Loney, Suphamungmee Worawit, Rixon, F.J., Jackson, David, Worawit Suphamungmee (418949), Rixon Frazer J., Vijayakrishnan, Swetha, Rixon, Frazer J., Loney, Colin, Bhella David, David Jackson, Loney, C., Suphamungmee, W., Jackson, D., Bhella, David, Vijayakrishnan, S., David Bhella (129684), Suphamungmee, Worawit, Frazer J Rixon   +29 more
core   +1 more source

Virus-like particles as vaccine adjuvants

Molecular Biotechnology, 2001
Virus-like particles (VLPs) consist of one or more viral coat proteins that assemble into particles. They can be taken up by antigen presenting cells (APC), peptides derived from them are presented on MHC class I molecules at the cell surface, and thereby prime a CD8+ T cell response, either against the particle-forming protein itself (such as ...
openaire   +3 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Post-authorisation experience and reported adverse events following use of a virus-like particle chikungunya vaccine, United States and Germany, up to August 2025

Eurosurveillance
Older adults are at increased risk of severe chikungunya. Some countries advise against vaccinating ≥ 60 or ≥ 65-year-olds with the licenced live-attenuated vaccine (CHIKV LA, IXCHIQ), following severe adverse event (SAE) reports.
Florian Lienert
doaj   +1 more source

Immunogenicity and safety of virus-like particle of the porcine encephalomyocarditis virus in pig

Virology Journal, 2011
Background In this study, porcine encephalomyocarditis virus (EMCV) virus-like particles (VLPs) were generated using a baculovirus expression system and were tested for immunogenicity and protective efficacy in vivo.
Shin Bo-Hye, Choi Hwan-Won, Jeong WooSeog, Lee Won-Ha, Jeoung Hye-Young, Lee Hee, An Dong-Jun   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source