Results 41 to 50 of about 6,611,706 (299)

Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope

Vaccines, 2022
The long-term storage stability of vaccines has a major impact on the roll-out and success of global immunization programs. For the Human Immunodeficiency Virus type 1 (HIV-1) virus-like particle (VLP) vaccine prototype evaluated here, nanoparticle ...
Diana Aguado-Garcia, Alex Olvera, Christian Brander, Victor Sanchez-Merino, Eloisa Yuste   +4 more
doaj   +1 more source

Virus imprinted particles [PDF]

, 2013
Living organisms are capable of identifying and neutralizing exogenous threats. Such a distinguishing feature, developed over millions of years of evolution, is achieved thanks to the immune system, and in particular through the molecular recognition ...
Cumbo, Alessandro
core   +1 more source

Ultrastructural aspects of virus replication in one fatal case and several other isolates from a dengue type 2 outbreak in Rio de Janeiro

Memorias do Instituto Oswaldo Cruz, 1994
Dengue virus replication in mosquito cell cultures was observed by electron microscopy in one fatal and 40 classical isolates from a dengue type 2 outbreak in Rio de Janeiro and compared with the prototype New Guinea C strain.
Ortrud Monika Barth, Luzia Monteiro de Castro Côrtes, Elisabeth Lampe, José da Costa Farias Filho   +3 more
doaj   +1 more source

Cryotomography of budding influenza a virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end [PDF]

, 2013
Influenza viruses exhibit striking variations in particle morphology between strains. Clinical isolates of influenza A virus have been shown to produce long filamentous particles while laboratory-adapted strains are predominantly spherical.
Swetha Vijayakrishnan, Vijayakrishnan Swetha, Jackson David, Worawit Suphamungmee, David Bhella, Loney Colin, Bhella, D., Swetha Vijayakrishnan (418947), Colin Loney (418948), David Jackson (84936), Frazer J. Rixon (129686), Colin Loney, Suphamungmee Worawit, Rixon, F.J., Jackson, David, Worawit Suphamungmee (418949), Rixon Frazer J., Vijayakrishnan, Swetha, Rixon, Frazer J., Loney, Colin, Bhella David, David Jackson, Loney, C., Suphamungmee, W., Jackson, D., Bhella, David, Vijayakrishnan, S., David Bhella (129684), Suphamungmee, Worawit, Frazer J Rixon   +29 more
core   +1 more source

The gag-like gene RTL8 antagonizes PEG10-mediated virus like particles

PLoS ONE
PEG10 is a retroelement-derived Mart-family gene that is necessary for placentation and has been implicated in neurological disease. PEG10 resembles both retrotransposon and retroviral proteins and forms virus-like particles (VLPs) that can be purified ...
Will Campodonico, Harihar M. Mohan, Phuoc T. Huynh, Holly H. Black, Cristina I. Lau, Henry L. Paulson, Lisa M. Sharkey, Alexandra M. Whiteley   +7 more
doaj   +2 more sources

Defective interfering particles of parainfluenza virus subtype 5 and interferon induction [PDF]

, 2015
The innate immune response is the first line of defence against virus infection. Cells contain a diverse array of pathogen recognition receptors (PRRs) that are able to recognise multiple pathogen associated molecular patterns (PAMPS) that present ...
Short, John A. L.
core   +2 more sources

The effects of high shear rates on the average hydrodynamic diameter measured in biomimetic HIV Gag virus-like particle dispersions

Frontiers in Bioengineering and Biotechnology
HIV Gag virus-like particles (HIV Gag VLPs) are promising HIV vaccine candidates. In the literature, they are often described as shear-sensitive particles, and authors usually recommend the operation of tangential flow filtration (TFF) gently at shear ...
Tobias Wolf, Tobias Wolf, Kerim Kadir Calisan, Jörn Stitz, Stéphan Barbe   +4 more
doaj   +1 more source

The structural basis for the integrity of adenovirus Ad3 dodecahedron [PDF]

, 2012
During the viral life cycle adenoviruses produce excess capsid proteins. Human adenovirus serotype 3 (Ad3) synthesizes predominantly an excess of free pentons, the complexes of pentameric penton base and trimeric fiber proteins, which are responsible for
Fender, Pascal, Monika Zochowska (134637), Jean-Pierre Andrieu, Ewa Szolajska (134629), Stephen Cusack (134664), Burmeister, Wim P, Pascal Fender (132764), Szolajska, Ewa, Pascal Fender, Nerlo, Barbara, Burmeister, Wim P., Igor Andreev, Wim P. Burmeister (134634), Wim P Burmeister, Guy Schoehn, Jadwiga Chroboczek (134668), Andreev, Igor, Naskalska, Antonina, Stephen Cusack, Chroboczek, Jadwiga, Barbara Nerlo (134643), Ewa Szolajska, Chloe Zubieta (134662), Barbara Nerlo, Igor Andreev (134649), Andrieu, Jean-Pierre, Jadwiga Chroboczek, Chloe Zubieta, Monika Zochowska, Zochowska, Monika, Cusack, Stephen, Jean-Pierre Andrieu (134655), Schoehn, Guy, Antonina Naskalska, Guy Schoehn (27525), Zubieta, Chloe, Antonina Naskalska (134660)   +36 more
core   +3 more sources

Preclinical Evaluation of Novel Sterically Optimized VLP-Based Vaccines against All Four DENV Serotypes

Vaccines
Over the past few decades, dengue fever has emerged as a significant global health threat, affecting tropical and moderate climate regions. Current vaccines have practical limitations, there is a strong need for safer, more effective options.
Dominik A. Rothen, Sudip Kumar Dutta, Pascal S. Krenger, Anne-Cathrine S. Vogt, Ilva Lieknina, Jan M. Sobczak, Albert D. M. E. Osterhaus, Mona O. Mohsen, Monique Vogel, Byron Martina, Kaspars Tars, Martin F. Bachmann   +11 more
doaj   +1 more source

Norwalk virus-like particles as vaccines [PDF]

Expert Review of Vaccines, 2010
Noroviruses (NoV) cause the great majority of epidemic nonbacterial gastroenteritis in humans. Expression of the capsid protein in recombinant systems, including insect and plant cells, yields assembly of virus-like particles (VLPs) that mimic the antigenic structure of authentic virions, and are relatively acid- and heat-stable.
Melissa, Herbst-Kralovetz, Hugh S, Mason, Qiang, Chen   +2 more
openaire   +2 more sources