Cytolytic Virus Activation Therapy for Epstein-Barr Virus–Driven Tumors [PDF]
Clinical Cancer Research, 2012 Abstract Purpose: Nasopharyngeal carcinoma (NPC) is causally linked to Epstein–Barr virus (EBV) infection. Because all tumor cells carry EBV, the virus itself is a potential target for therapy. In these tumor cells, EBV hides in a latent state and expresses only a few non-immunogenic proteins for EBV maintenance and contributes to ...
Wildeman, M.A. +8 more
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The virion host shut-off (vhs) protein blocks a TLR-independent pathway of herpes simplex virus type 1 recognition in human and mouse dendritic cells. [PDF]
PLoS ONE, 2010 Molecular pathways underlying the activation of dendritic cells (DCs) in response to Herpes Simplex Virus type 1 (HSV-1) are poorly understood. Removal of the HSV virion host shut-off (vhs) protein relieves a block to DC activation observed during wild ...
Christopher R Cotter +5 more
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Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication. [PDF]
PLoS Pathogens, 2017 Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility.
Sharon K Kuss-Duerkop +13 more
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Mast Cells Modulate Antigen-Specific CD8+ T Cell Activation During LCMV Infection
Frontiers in Immunology, 2021 Mast cells (MCs), strategically localized at mucosal surfaces, provide first-line defense against pathogens and shape innate and adaptive immune responses.
Yana Hackler +6 more
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Polyoma virus minichromosomes: associated enzyme activities [PDF]
Journal of Virology, 1981 Polyoma minichromosomes were isolated and fractionated on glycerol gradients as described by Gourlie et al. (J. Virol. 38:805-814, 1981). Specific assays for DNa polymerases alpha, beta, and gamma, DNA topoisomerase I, and RNase H were carried out on each fraction.
B B, Gourlie +5 more
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Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome
Frontiers in Immunology, 2020 Dengue is the most prevalent and rapidly transmitted mosquito-borne viral disease of humans. One of the fundamental innate immune responses to viral infections includes the processing and release of pro-inflammatory cytokines such as interleukin (IL-1β ...
Gaurav Shrivastava +8 more
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Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway. [PDF]
PLoS ONE, 2011 BACKGROUND: We have shown previously in mice, that infection with live viruses, including influenza/A and Semliki Forest virus (SFV), induces systemic partial activation of lymphocytes, characterized by cell surface expression of CD69 and CD86, but not ...
Yoichi Furuya +8 more
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Anti-zika virus activity of polyoxometalates [PDF]
Antiviral Research, 2019 Zika virus (ZIKV) is an emerging infectious viral pathogen associated with severe fetal cerebral anomalies and the paralytic Guillain-Barrè syndrome in adults. It was the cause of a recent global health crisis following its entrance into a naïve population in the Americas. Nowadays, no vaccine or specific antiviral against ZIKV is available.
Francese, Rachele +8 more
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A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier [PDF]
Clinical and Molecular Hepatology, 2012 Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended.
Joong Ho Bae +8 more
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Virus Inhibitory Activity of Polyvinylamine.
Experimental Biology and Medicine, 1954 SummaryA comparative study of the virus inhibitory efficacy of the synthetic basic polypeptide, polylysine, and the synthetic basic polymer, polyvinylamine, revealed that both polymers inhibited the production of influenza B virus in the chick embryo.
M, GREEN, M A, STAHMANN
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